ID   DKAT
AC   CVCL_VQ65
DR   cancercelllines; CVCL_VQ65
DR   GEO; GSM820811
DR   GEO; GSM820812
DR   GEO; GSM820813
DR   Lonza; 1676
DR   Wikidata; Q93527903
RX   Patent=US20110085982;
RX   PubMed=23049838;
CC   Group: Patented cell line.
CC   Group: Triple negative breast cancer (TNBC) cell line.
CC   Registration: International Depositary Authority, American Type Culture Collection (ATCC); PTA-10322.
CC   Characteristics: Highly tumorigenic. Only 10 DKAT cells are needed to form, in immunocompromised mice, xenograft tumors which display a range of epithelial and mesenchymal phenotypes (PubMed=23049838).
CC   Doubling time: ~24 hours (PubMed=23049838).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Heterozygous (PubMed=23049838).
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C4872; Breast carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   35Y
CA   Cancer cell line
DT   Created: 13-11-18; Last updated: 05-10-23; Version: 8
//
RX   Patent=US20110085982;
RA   Seewaldt V.L., D'Amato N.C., Ostrander J.H.;
RT   "DKAT cell line, a model for human triple-negative breast cancer.";
RL   Patent number US20110085982, 14-Apr-2011.
//
RX   PubMed=23049838; DOI=10.1371/journal.pone.0045684;
RA   D'Amato N.C., Ostrander J.H., Bowie M.L., Sistrunk C., Borowsky A.D.,
RA   Cardiff R.D., Bell K., Young L.J.T., Simin K., Bachelder R.E.,
RA   Delrow J.J., Dawson A., Yee L.D., Mrozek K., Clay T.M., Osada T.,
RA   Seewaldt V.L.;
RT   "Evidence for phenotypic plasticity in aggressive triple-negative
RT   breast cancer: human biology is recapitulated by a novel model
RT   system.";
RL   PLoS ONE 7:E45684-E45684(2012).
//