Cellosaurus cell line SKX (CVCL

Cellosaurus SKX (CVCL_VP43)

Cross-references
Cell line name	SKX
Accession	CVCL_VP43
Resource Identification Initiative	To cite this cell line use: SKX (RRID:CVCL_VP43)
Comments	Characteristics: Established from a xenograft developed by serial transplantation of the original tumor in nude mice. Characteristics: Defective in double-strand break (DSB) DNA repair. Highly radiosensitive, has a a TCD50 value of 19.8 Gy (PubMed=19038467).
Sequence variations	Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg249Ser (c.747G>T); ClinVar=VCV000012352; Zygosity=Unspecified (CelloPub=CLPUB00439; PubMed=11799138).
Disease	Floor of mouth squamous cell carcinoma (NCIt: C4041) Squamous cell carcinoma of the oral cavity (ORDO: Orphanet_502363)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Sex unspecified
Age at sampling	83Y
Category	Cancer cell line
Publications	CLPUB00439 Dorfler A., Eicheler W., Zips D., Petersen C., Baumann M. Establishment and characterization of a radiation-sensitive squamous cell carcinoma -- SKX -- cell line in vitro. Exp. Strahlenther. Klin. Strahlenbiol. 9:11-13(2000) PubMed=11799138; DOI=10.1177/002215540205000207 Eicheler W., Zips D., Dorfler A., Grenman R., Baumann M. Splicing mutations in TP53 in human squamous cell carcinoma lines influence immunohistochemical detection. J. Histochem. Cytochem. 50:197-204(2002) PubMed=19038467; DOI=10.1016/j.radonc.2008.10.019 Kasten-Pisula U., Menegakis A., Brammer I., Borgmann K., Mansour W.Y., Degenhardt S., Krause M., Schreiber A., Dahm-Daphi J., Petersen C., Dikomey E., Baumann M. The extreme radiosensitivity of the squamous cell carcinoma SKX is due to a defect in double-strand break repair. Radiother. Oncol. 90:257-264(2009)
Cell line databases/resources	cancercelllines; CVCL_VP43
Encyclopedic resources	Wikidata; Q98132686
Polymorphism and mutation databases	IARC_TP53; 17653
Entry history
Entry creation	07-Sep-2018
Last entry update	19-Dec-2024
Version number	10