ID   SKX
AC   CVCL_VP43
DR   cancercelllines; CVCL_VP43
DR   IARC_TP53; 17653
DR   Wikidata; Q98132686
RX   CelloPub=CLPUB00439;
RX   PubMed=11799138;
RX   PubMed=19038467;
CC   Characteristics: Established from a xenograft developed by serial transplantation of the original tumor in nude mice.
CC   Characteristics: Defective in double-strand break (DSB) DNA repair. Highly radiosensitive, has a a TCD50 value of 19.8 Gy (PubMed=19038467).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg249Ser (c.747G>T); ClinVar=VCV000012352; Zygosity=Unspecified (CelloPub=CLPUB00439; PubMed=11799138).
DI   NCIt; C4041; Floor of mouth squamous cell carcinoma
DI   ORDO; Orphanet_502363; Squamous cell carcinoma of the oral cavity
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Sex unspecified
AG   83Y
CA   Cancer cell line
DT   Created: 07-09-18; Last updated: 19-12-24; Version: 10
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RX   CelloPub=CLPUB00439;
RA   Dorfler A., Eicheler W., Zips D., Petersen C., Baumann M.;
RT   "Establishment and characterization of a radiation-sensitive
RT   squamous cell carcinoma -- SKX -- cell line in vitro.";
RL   Exp. Strahlenther. Klin. Strahlenbiol. 9:11-13(2000).
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RX   PubMed=11799138; DOI=10.1177/002215540205000207;
RA   Eicheler W., Zips D., Dorfler A., Grenman R., Baumann M.;
RT   "Splicing mutations in TP53 in human squamous cell carcinoma lines
RT   influence immunohistochemical detection.";
RL   J. Histochem. Cytochem. 50:197-204(2002).
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RX   PubMed=19038467; DOI=10.1016/j.radonc.2008.10.019;
RA   Kasten-Pisula U., Menegakis A., Brammer I., Borgmann K., Mansour W.Y.,
RA   Degenhardt S., Krause M., Schreiber A., Dahm-Daphi J., Petersen C.,
RA   Dikomey E., Baumann M.;
RT   "The extreme radiosensitivity of the squamous cell carcinoma SKX is
RT   due to a defect in double-strand break repair.";
RL   Radiother. Oncol. 90:257-264(2009).
//