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Cellosaurus LMWT5 (CVCL_VN52)

[Text version]
Cell line name LMWT5
Accession CVCL_VN52
Resource Identification Initiative To cite this cell line use: LMWT5 (RRID:CVCL_VN52)
Comments Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Mutation; HGNC; HGNC:9065; PLCG1; Simple; p.Arg748His (c.2243G>A); Zygosity=Heterozygous (CelloPub=CLPUB00592).
  • Mutation; HGNC; HGNC:9065; PLCG1; Simple; p.Ser520Phe (c.1559C>T); Zygosity=Heterozygous (CelloPub=CLPUB00592).
Disease Adult T acute lymphoblastic leukemia (NCIt: C9142)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Category Cancer cell line
Publications

PubMed=27193821; DOI=10.1111/cas.12971; PMCID=PMC4982578
Hasegawa H., Bissonnette R.P., Gillings M., Sasaki D., Taniguchi H., Kitanosono H., Tsuruda K., Kosai K., Uno N., Morinaga Y., Imaizumi Y., Miyazaki Y., Yanagihara K.
Induction of apoptosis by HBI-8000 in adult T-cell leukemia/lymphoma is associated with activation of Bim and NLRP3.
Cancer Sci. 107:1124-1133(2016)

CLPUB00592
Patel V.M.
Functional interrogations of phospholipase c gamma 1 (PLCG1) mutations in Sezary syndrome.
Thesis PhD (2019); King's College London; London; United Kingdom

Cross-references
Encyclopedic resources Wikidata; Q95982649
Entry history
Entry creation07-Sep-2018
Last entry update19-Dec-2024
Version number9