ID   LMWT5
AC   CVCL_VN52
DR   Wikidata; Q95982649
RX   CelloPub=CLPUB00592;
RX   PubMed=27193821;
CC   Sequence variation: Mutation; HGNC; HGNC:9065; PLCG1; Simple; p.Arg748His (c.2243G>A); Zygosity=Heterozygous (CelloPub=CLPUB00592).
CC   Sequence variation: Mutation; HGNC; HGNC:9065; PLCG1; Simple; p.Ser520Phe (c.1559C>T); Zygosity=Heterozygous (CelloPub=CLPUB00592).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: T-cell; CL=CL_0000084.
DI   NCIt; C9142; Adult T acute lymphoblastic leukemia
DI   ORDO; Orphanet_99861; Precursor T-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
CA   Cancer cell line
DT   Created: 07-09-18; Last updated: 19-12-24; Version: 9
//
RX   CelloPub=CLPUB00592;
RA   Patel V.M.;
RT   "Functional interrogations of phospholipase c gamma 1 (PLCG1)
RT   mutations in Sezary syndrome.";
RL   Thesis PhD (2019); King's College London; London; United Kingdom.
//
RX   PubMed=27193821; DOI=10.1111/cas.12971; PMCID=PMC4982578;
RA   Hasegawa H., Bissonnette R.P., Gillings M., Sasaki D., Taniguchi H.,
RA   Kitanosono H., Tsuruda K., Kosai K., Uno N., Morinaga Y., Imaizumi Y.,
RA   Miyazaki Y., Yanagihara K.;
RT   "Induction of apoptosis by HBI-8000 in adult T-cell leukemia/lymphoma
RT   is associated with activation of Bim and NLRP3.";
RL   Cancer Sci. 107:1124-1133(2016).
//