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Cellosaurus ORL-196 (CVCL_VJ44)

[Text version]
Cell line name ORL-196
Synonyms ORL-196T; 196T
Accession CVCL_VJ44
Resource Identification Initiative To cite this cell line use: ORL-196 (RRID:CVCL_VJ44)
Comments Population: Indian.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Oral cavity, buccal mucosa; UBERON=UBERON_0006956.
Sequence variations
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Arg80Ter (c.238C>T) (p.Pro94Leu, c.281C>T); ClinVar=VCV000009409; Zygosity=Homozygous (PubMed=27050151).
  • Mutation; HGNC; HGNC:3595; FAT1; Simple; p.Leu398Phefs*6 (c.1193dup); Zygosity=Unspecified (PubMed=27050151).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Lys321Asnfs*24 (c.960delG); Zygosity=Unspecified (PubMed=24224046; PubMed=27050151).
Disease Buccal mucosa squamous cell carcinoma (NCIt: C4040)
Squamous cell carcinoma of the oral cavity (ORDO: Orphanet_502363)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 59Y
Category Cancer cell line
STR profile Source(s): PubMed=27050151

Markers:
AmelogeninX
CSF1PO10,12
D2S133822,23
D3S135814,17
D5S81813,14
D7S8208
D8S117913,15
D13S31712
D16S53912,13
D18S5115
D19S43314.2,16
D21S1129,32.2
FGA21,22
TH016,7
TPOX8,11
vWA14,16

Run an STR similarity search on this cell line
Publications

PubMed=24224046; DOI=10.1371/journal.pone.0080229; PMCID=PMC3817115
Zanaruddin S.N.S., Yee P.-S., Hor S.Y., Kong Y.H., Ghani W.M.N.W.A., Mustafa W.M.W., Zain R.B., Prime S.S., Rahman Z.A.A., Cheong S.-C.
Common oncogenic mutations are infrequent in oral squamous cell carcinoma of Asian origin.
PLoS ONE 8:E80229-E80229(2013)

PubMed=27050151; DOI=10.18632/oncotarget.8533; PMCID=PMC5053689
Fadlullah M.Z.H., Chiang I.K.-N., Dionne K.R., Yee P.-S., Gan C.P., Sam K.K., Tiong K.H., Ng A.K.W., Martin D., Lim K.P., Kallarakkal T.G., Mustafa W.M.W., Lau S.H., Abraham M.T., Zain R.B., Rahman Z.A.A., Molinolo A.A., Patel V., Gutkind J.S., Tan A.-C., Cheong S.-C.
Genetically-defined novel oral squamous cell carcinoma cell lines for the development of molecular therapies.
Oncotarget 7:27802-27818(2016)

Cross-references
Cell line databases/resources cancercelllines; CVCL_VJ44
Encyclopedic resources Wikidata; Q98128364
Polymorphism and mutation databases Cosmic; 2531646
Cosmic; 2559744
Entry history
Entry creation07-Sep-2018
Last entry update19-Dec-2024
Version number9