Cellosaurus cell line US/VOT-E36 (CVCL

Cellosaurus US/VOT-E36 (CVCL_VC36)

Cross-references
Cell line name	US/VOT-E36
Synonyms	VOT-E36; University of Sheffield/Ventral OTocyst-Epithelial 36
Accession	CVCL_VC36
Resource Identification Initiative	To cite this cell line use: US/VOT-E36 (RRID:CVCL_VC36)
Comments	Characteristics: Suitable for studies on inner ear development, gene expression and function of inner ear-specific genes, in vitro screening for gene activation and promoter analysis, ototoxicity and in vitro analysis of inherited deafness mutations and of ion channels, receptors and signalling pathways in vitro. Genetic integration: Method=Transgenic mouse; Gene=UniProtKB; P03070; SV40 large T antigen. Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=tsA58). Derived from site: In situ; Embryonic ear, inner ear, otocyst; UBERON=UBERON_0003051. Cell type: Epithelial cell; CL=CL_0000066.
Species of origin	Mus musculus (Mouse) (NCBI Taxonomy: 10090) Breed/subspecies: (CBA/Ca x C57BL/10)Tg(H2Kb-tsA58) Immortomouse.
Sex of cell	Sex unspecified
Age at sampling	10-11FD
Category	Conditionally immortalized cell line
Web pages	https://licensing.sheffield.ac.uk/fileserver/5
Publications	PubMed=15499550; DOI=10.1002/dvdy.20187 Lawoko-Kerali G., Milo M., Davies D., Halsall A., Helyer R.J., Johnson C.M., Rivolta M.N., Tones M.A., Holley M.C. Ventral otic cell lines as developmental models of auditory epithelial and neural precursors. Dev. Dyn. 231:801-814(2004) PubMed=17331193; DOI=10.1111/j.1460-9568.2007.05338.x Helyer R.J., Cacciabue-Rivolta D.I., Davies D., Rivolta M.N., Kros C.J., Holley M.C. A model for mammalian cochlear hair cell differentiation in vitro: effects of retinoic acid on cytoskeletal proteins and potassium conductances. Eur. J. Neurosci. 25:957-973(2007)
Cell line collections (Providers)	CancerTools; 153625 Ximbio; 153625
Encyclopedic resources	Wikidata; Q54991846
Entry history
Entry creation	14-May-2018
Last entry update	10-Sep-2024
Version number	10