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Cellosaurus US/VOT-E36 (CVCL_VC36)

[Text version]
Cell line name US/VOT-E36
Synonyms VOT-E36; University of Sheffield/Ventral OTocyst-Epithelial 36
Accession CVCL_VC36
Resource Identification Initiative To cite this cell line use: US/VOT-E36 (RRID:CVCL_VC36)
Comments Characteristics: Suitable for studies on inner ear development, gene expression and function of inner ear-specific genes, in vitro screening for gene activation and promoter analysis, ototoxicity and in vitro analysis of inherited deafness mutations and of ion channels, receptors and signalling pathways in vitro.
Genetic integration: Method=Transgenic mouse; Gene=UniProtKB; P03070; SV40 large T antigen.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=tsA58).
Derived from site: In situ; Embryonic ear, inner ear, otocyst; UBERON=UBERON_0003051.
Cell type: Epithelial cell; CL=CL_0000066.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: (CBA/Ca x C57BL/10)Tg(H2Kb-tsA58) Immortomouse.
Sex of cell Sex unspecified
Age at sampling 10-11FD
Category Conditionally immortalized cell line
Publications

PubMed=15499550; DOI=10.1002/dvdy.20187
Lawoko-Kerali G., Milo M., Davies D., Halsall A., Helyer R.J., Johnson C.M., Rivolta M.N., Tones M.A., Holley M.C.
Ventral otic cell lines as developmental models of auditory epithelial and neural precursors.
Dev. Dyn. 231:801-814(2004)

PubMed=17331193; DOI=10.1111/j.1460-9568.2007.05338.x
Helyer R.J., Cacciabue-Rivolta D.I., Davies D., Rivolta M.N., Kros C.J., Holley M.C.
A model for mammalian cochlear hair cell differentiation in vitro: effects of retinoic acid on cytoskeletal proteins and potassium conductances.
Eur. J. Neurosci. 25:957-973(2007)

Cross-references
Cell line collections (Providers) CancerTools; 153625
Ximbio; 153625
Encyclopedic resources Wikidata; Q54991846
Entry history
Entry creation14-May-2018
Last entry update10-Apr-2025
Version number11