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Cellosaurus U2-OS Tet-On (CVCL_V335)

[Text version]
Cell line name U2-OS Tet-On
Accession CVCL_V335
Resource Identification Initiative To cite this cell line use: U2-OS Tet-On (RRID:CVCL_V335)
Comments Population: Caucasian.
Characteristics: Transfected with reverse tetracycline-controlled transactivator (rtTA), a fusion between a mutated version of E.coli TetR and the activating domain of HSV-1 VP16.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P04483; Escherichia coli Tn10 tetR.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P06492; Human herpesvirus 1 VP16 (UL28) (Note=With p.Met1_Arg360del).
Derived from site: In situ; Bone, tibia; UBERON=UBERON_0000979.
Sequence variations
  • Mutation; HGNC; HGNC:9277; PPM1D; Simple; p.Arg458Ter (c.1372C>T); ClinVar=VCV002445214; Zygosity=Heterozygous (from parent cell line).
Disease Osteosarcoma (NCIt: C9145)
Osteosarcoma (ORDO: Orphanet_668)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0042 (U2OS)
Sex of cell Female
Age at sampling 15Y
Category Cancer cell line
Web pages http://www.clontech.com/xxclt_ibcGetAttachment.jsp?cItemId=26894
Cross-references
Encyclopedic resources Wikidata; Q54973628
Entry history
Entry creation16-Apr-2014
Last entry update19-Dec-2024
Version number14