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Cellosaurus HT-1080-Luc2 (CVCL_UZ99)

[Text version]
Cell line name HT-1080-Luc2
Accession CVCL_UZ99
Resource Identification Initiative To cite this cell line use: HT-1080-Luc2 (RRID:CVCL_UZ99)
Comments Population: Caucasian.
Characteristics: Stably expresses firefly luciferase under the control of the human EF1a promoter (ATCC=CCL-121-LUC2).
Doubling time: ~11 hours (ATCC=CCL-121-LUC2).
Genetic integration: Method=Transduction; Gene=UniProtKB; P08659; Firefly luciferase (Note=With optimized codon usage for mammalian expression).
Genetic integration: Method=Transduction; Gene=UniProtKB; P33967; B.cereus Bsr.
Derived from site: In situ; Bone, pelvis, acetabulum; UBERON=UBERON_0001269.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:5382; IDH1; Simple; p.Arg132Cys (c.394C>T); ClinVar=VCV000375891; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
Disease Fibrosarcoma (NCIt: C3043)
Fibrosarcoma (ORDO: Orphanet_2030)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0317 (HT-1080)
Sex of cell Male
Age at sampling 35Y
Category Cancer cell line
STR profile Source(s): ATCC=CCL-121-LUC2

Markers:
AmelogeninX,Y
CSF1PO12
D5S81811,13
D7S8209,10
D13S31712,14
D16S5399,12
TH016
TPOX8
vWA14,19

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Cross-references
Cell line collections (Providers) ATCC; CCL-121-LUC2
Cell line databases/resources cancercelllines; CVCL_UZ99
Encyclopedic resources Wikidata; Q94304256
Entry history
Entry creation25-Feb-2019
Last entry update19-Dec-2024
Version number14