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Cellosaurus hTERT NF1 ipnNF09.4 (CVCL_UI73)

[Text version]
Cell line name hTERT NF1 ipnNF09.4
Synonyms ipnNF09.4
Accession CVCL_UI73
Resource Identification Initiative To cite this cell line use: hTERT NF1 ipnNF09.4 (RRID:CVCL_UI73)
Comments Population: Caucasian.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
Genetic integration: Method=Transduction; Gene=MGI; MGI:88357; Cdk4.
Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Derived from site: In situ; Peripheral nervous system, nerve; UBERON=UBERON_0001021.
Cell type: Schwann cell; CL=CL_0002573.
Sequence variations
  • Mutation; HGNC; HGNC:7765; NF1; Simple; p.Leu1153Thrfs*42 (c.3456dupA) (3456_3457insA); ClinVar=VCV000656975; Zygosity=Heterozygous; Note=Germline (PubMed=27617404).
Disease Neurofibromatosis type 1 (NCIt: C3273)
Neurofibromatosis type 1 (ORDO: Orphanet_636)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_UI71 ! hTERT NF1 ipNF05.5
CVCL_UI72 ! hTERT NF1 ipNF05.5 (Mixed clones)
Sex of cell Male
Age at sampling 22Y
Category Telomerase immortalized cell line
Publications

PubMed=27617404; DOI=10.1038/labinvest.2016.88
Li H., Chang L.-J., Neubauer D.R., Muir D.F. 4th, Wallace M.R.
Immortalization of human normal and NF1 neurofibroma Schwann cells.
Lab. Invest. 96:1105-1115(2016)

Cross-references
Cell line collections (Providers) ABM; T0195
Encyclopedic resources Wikidata; Q94305854
Entry history
Entry creation25-Feb-2019
Last entry update19-Dec-2024
Version number12