Cellosaurus logo
expasy logo

Cellosaurus UCSD237i-APP1-2 APPnull (CVCL_UI23)

[Text version]
Cell line name UCSD237i-APP1-2 APPnull
Synonyms APPDp1.2 APPnull; APP 1KO; APPnull in APPdp1.2 background
Accession CVCL_UI23
Resource Identification Initiative To cite this cell line use: UCSD237i-APP1-2 APPnull (RRID:CVCL_UI23)
Comments Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:620; APP.
Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Cell type: Fibroblast of skin; CL=CL_0002620.
Disease Familial Alzheimer's disease, type 1 (NCIt: C146894)
Early-onset autosomal dominant Alzheimer disease (ORDO: Orphanet_1020)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_EJ97 (UCSD237i-APP1-2)
Sex of cell Male
Age at sampling 51Y
Category Induced pluripotent stem cell
Publications

PubMed=30686764; DOI=10.1016/j.stem.2018.12.013; PMCID=PMC6414424
van der Kant R., Langness V.F., Herrera C.M., Williams D.A., Fong L.K., Leestemaker Y., Steenvoorden E., Rynearson K.D., Brouwers J.F., Helms J.B., Ovaa H., Giera M., Wagner S.L., Bang A.G., Goldstein L.S.B.
Cholesterol metabolism is a druggable axis that independently regulates Tau and amyloid-beta in iPSC-derived Alzheimer's disease neurons.
Cell Stem Cell 24:363-375.e9(2019)

Cross-references
Encyclopedic resources Wikidata; Q98133861
Entry history
Entry creation25-Feb-2019
Last entry update19-Dec-2024
Version number7