ID   UCSD237i-APP1-2 APPnull
AC   CVCL_UI23
SY   APPDp1.2 APPnull; APP 1KO; APPnull in APPdp1.2 background
DR   Wikidata; Q98133861
RX   PubMed=30686764;
CC   Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:620; APP.
CC   Derived from site: In situ; Skin; UBERON=UBERON_0002097.
CC   Cell type: Fibroblast of skin; CL=CL_0002620.
DI   NCIt; C146894; Alzheimer's disease 1
DI   ORDO; Orphanet_1020; Early-onset autosomal dominant Alzheimer disease
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_EJ97 ! UCSD237i-APP1-2
SX   Male
AG   51Y
CA   Induced pluripotent stem cell
DT   Created: 25-02-19; Last updated: 10-04-25; Version: 8
//
RX   PubMed=30686764; DOI=10.1016/j.stem.2018.12.013; PMCID=PMC6414424;
RA   van der Kant, Rik
RA   Langness, Vanessa F.
RA   Herrera, Cheryl M.
RA   Williams, Daniel A.
RA   Fong, Lauren K.
RA   Leestemaker, Yves
RA   Steenvoorden, Evelyne
RA   Rynearson, Kevin D.
RA   Brouwers, Jos F.
RA   Helms, J. Bernd
RA   Ovaa, Huib
RA   Giera, Martin
RA   Wagner, Steven L.
RA   Bang, Anne G.
RA   Goldstein, Lawrence Steven B.
RT   "Cholesterol metabolism is a druggable axis that independently
RT   regulates Tau and amyloid-beta in iPSC-derived Alzheimer's disease
RT   neurons.";
RL   Cell Stem Cell 24:363-375.e9(2019).
//