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Cellosaurus TF-1 IDH2 p.R140Q (CVCL_UE10)

[Text version]
Cell line name TF-1 IDH2 p.R140Q
Synonyms IDH2 mutant-TF-1 Isogenic Cell Line
Accession CVCL_UE10
Resource Identification Initiative To cite this cell line use: TF-1 IDH2 p.R140Q (RRID:CVCL_UE10)
Comments Population: Japanese.
Characteristics: Compared to the parent cell line, has elevated intra- and extracellular D-2-hydroxyglutarate (D-2HG) levels (ATCC=CRL-2003IG).
Doubling time: ~24.8 hours (ATCC=CRL-2003IG).
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Gene fusion; HGNC; HGNC:15868; ABHD12 + HGNC; HGNC:1537; CBFA2T3; Name(s)=CBFA2T3-ABHD12 (from parent cell line).
  • Mutation; HGNC; HGNC:5383; IDH2; Simple_edited; p.Arg140Gln (c.419G>A); ClinVar=VCV000014716; Zygosity=Homozygous; Note=By CRISPR/Cas9 (ATCC=CRL-2003IG).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Pro (c.182A>C); ClinVar=VCV000280409; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ile251Thrfs*94 (c.752delT); ClinVar=VCV001759367; Zygosity=Unspecified (from parent cell line).
Disease Erythroleukemia (NCIt: C7152)
Acute erythroid leukemia (ORDO: Orphanet_318)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0559 (TF-1)
Children:
CVCL_A4BL (TF-1 IDH2 p.R140Q-Luc2)
Sex of cell Male
Age at sampling 35Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-2003IG

Markers:
AmelogeninX,Y
CSF1PO13
D5S81813
D7S82012
D13S3178,9
D16S5399,12
TH018
TPOX7,9
vWA15,17

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Web pages https://www.atcc.org/en/support/technical-support/faqs/idh2-mutant-tf-1-isogenic-cell-line-atcc-crl-2003ig
Cross-references
Cell line collections (Providers) ATCC; CRL-2003IG
Cell line databases/resources cancercelllines; CVCL_UE10
Encyclopedic resources Wikidata; Q98133229
Entry history
Entry creation13-Nov-2018
Last entry update19-Dec-2024
Version number13