Cellosaurus cell line Nalm-6-TK+/- (CVCL

Cellosaurus Nalm-6-TK+/- (CVCL_UD96)

[Text version]

Cell line name

Nalm-6-TK+/-

Accession

CVCL_UD96

Resource Identification Initiative

To cite this cell line use: Nalm-6-TK+/- (RRID:CVCL_UD96)

Comments

Population: Caucasian.
Knockout cell: Method=Homologous recombination; HGNC; HGNC:11830; TK1 (Note=1 of 2 alleles).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.

Sequence variations

Gene fusion; HGNC; HGNC:50800; DUX4 + HGNC; HGNC:5477; IGH; Name(s)=IGH-DUX4; Note=The translocation occurs in the silenced IGH allele (from parent cell line).
Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Arg1068Ter (c.3202C>T); Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Ala146Thr (c.436G>A); Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; HGNC:9864; RARA; Simple; p.Gln45Ter (c.133C>T); ClinVar=VCV000393019; Zygosity=Heterozygous (from parent cell line).

Disease

Adult B acute lymphoblastic leukemia (NCIt: C9143)
Precursor B-cell acute lymphoblastic leukemia (ORDO: Orphanet_99860)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy

Parent: CVCL_0092 (NALM-6)
Children:

CVCL_M247 (POLH KO MSH-)	CVCL_JH02 (POLK CD MSH-)	CVCL_4W71 (POLK F171A MSH-)
CVCL_4W72 (POLK KO hetero MSH-)	CVCL_4W73 (POLK KO homo MSH-)	CVCL_JH03 (POLK SG MSH-)

Sex of cell

Male

Age at sampling

19Y