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Cellosaurus LM-MEL-3 (CVCL_UC18)

[Text version]
Cell line name LM-MEL-3
Synonyms LM-Mel-3; Ludwig Melbourne-MELanoma-3
Accession CVCL_UC18
Resource Identification Initiative To cite this cell line use: LM-MEL-3 (RRID:CVCL_UC18)
Comments Part of: Ludwig Institute for Cancer Research Melbourne melanoma cell line panel.
Omics: miRNA expression profiling.
Omics: Transcriptome analysis by microarray.
Miscellaneous: MAP2K1 mutation, metastatic site and STR profile from personal communication of Cardwell T., Olivia Newton-John Cancer Research Institute.
Derived from site: Metastatic; Skin; UBERON=UBERON_0002097.
Sequence variations
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (PubMed=23527996).
  • Mutation; HGNC; 6840; MAP2K1; Simple; p.Pro124Leu (c.371C>T); ClinVar=VCV000040744; Zygosity=Heterozygous (Direct_author_submission).
HLA typing Source: PubMed=23527996
Class I
HLA-AA*01:01,24:02
HLA-BB*07:02,08:01
HLA-CC*07:01,07:02
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 54Y
Category Cancer cell line
STR profile Source(s): Direct_author_submission

Markers:
AmelogeninX
CSF1PO13
D5S81812
D7S82010,12
D13S31711,12
D16S53913,14
D21S1129
TH017,9.3
TPOX8,11
vWA17

Run an STR similarity search on this cell line
Publications

PubMed=18957296; DOI=10.1016/j.jim.2008.09.023
Dimopoulos N., Jackson H.M., Ebert L., Guillaume P., Luescher I.F., Ritter G., Chen W.-S.
Combining MHC tetramer and intracellular cytokine staining for CD8(+) T cells to reveal antigenic epitopes naturally presented on tumor cells.
J. Immunol. Methods 340:90-94(2009)

PubMed=23527996; DOI=10.1111/pcmr.12097
Behren A., Anaka M., Lo P.-H., Vella L.J., Davis I.D., Catimel J., Cardwell T., Gedye C., Hudson C., Stan R., Cebon J.S.
The Ludwig Institute for Cancer Research Melbourne melanoma cell line panel.
Pigment Cell Melanoma Res. 26:597-600(2013)

PubMed=27852308; DOI=10.1186/s12943-016-0554-y
Andrews M.C., Cursons J., Hurley D.G., Anaka M., Cebon J.S., Behren A., Crampin E.J.
Systems analysis identifies miR-29b regulation of invasiveness in melanoma.
Mol. Cancer 15:72.1-72.20(2016)

Cross-references
Cell line databases/resources cancercelllines; CVCL_UC18
Encyclopedic resources Wikidata; Q95982518
Gene expression databases ArrayExpress; E-MTAB-1496
GEO; GSM2371743
Entry history
Entry creation13-Nov-2018
Last entry update05-Oct-2023
Version number10