Cell line name |
6T-CEM20 |
Synonyms |
6T-CEM-20; 6-T CEM-20; 6TCEM20 |
Accession |
CVCL_U293 |
Resource Identification Initiative |
To cite this cell line use: 6T-CEM20 (RRID:CVCL_U293) |
Comments |
Group: Patented cell line. Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-8295. Population: Caucasian. Selected for resistance to: ChEBI; CHEBI_9555; Tioguanine (6-thioguanine; 6-TG). Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178. Cell type: T-cell; CL=CL_0000084. |
Sequence variations |
- Gene fusion; HGNC; HGNC:13222; BCL11B + HGNC; HGNC:2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
- Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
|
Disease |
Childhood T acute lymphoblastic leukemia (NCIt: C7953) Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_6869 (6T-CEM) |
Sex of cell |
Female |
Age at sampling |
3Y11M |
Category |
Cancer cell line |
Publications | PubMed=6234996; DOI=10.1016/0008-8749(84)90128-X Lau C.Y., Budz-Tymkewycz S., Wang E.Y., Ishaque A. A mutant human T-cell line producing immunosuppressive factor(s). Cell. Immunol. 87:35-52(1984) Patent=US4705687 Lau C.Y. Treatment of autoimmune diseases such as rheumatoid arthritis with suppressor factor. Patent number US4705687, 10-Nov-1987 Patent=US4728614 Lau C.Y. Mutant human T cell line producing immunosuppressive factor and method for obtaining such mutants. Patent number US4728614, 01-Mar-1988 |
Cross-references |
Cell line databases/resources |
cancercelllines; CVCL_U293
|
Encyclopedic resources |
Wikidata; Q54604614
|
Entry history |
Entry creation | 03-Feb-2014 |
Last entry update | 19-Dec-2024 |
Version number | 21 |
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