Cell line name |
6T-CEM |
Synonyms |
6-T CEM |
Accession |
CVCL_6869 |
Resource Identification Initiative |
To cite this cell line use: 6T-CEM (RRID:CVCL_6869) |
Comments |
Group: Patented cell line. Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-8296. Population: Caucasian. Selected for resistance to: ChEBI; CHEBI_9555; Tioguanine (6-thioguanine; 6-TG). Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178. Cell type: T-cell; CL=CL_0000084. |
Sequence variations |
- Gene fusion; HGNC; HGNC:13222; BCL11B + HGNC; HGNC:2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
- Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
|
Disease |
Childhood T acute lymphoblastic leukemia (NCIt: C7953) Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_0207 (CCRF-CEM) Children:
|
Sex of cell |
Female |
Age at sampling |
3Y11M |
Category |
Cancer cell line |
STR profile |
Source(s): ATCC=CRL-8296; CCRID=3101HUMTCHu2; CLS=305132
Markers:Amelogenin | X |
CSF1PO | 10,11 |
D2S1338 | 24 |
D3S1358 | 14,15 (CCRID=3101HUMTCHu2) 15 (CLS=305132) |
D5S818 | 11,12,13 (ATCC=CRL-8296) 11,13 (CCRID=3101HUMTCHu2; CLS=305132) |
D6S1043 | 11,14 |
D7S820 | 9,14 |
D8S1179 | 13 |
D12S391 | 17,18,20,21 |
D13S317 | 11,12 |
D16S539 | 10,13 |
D18S51 | 13,18 |
D19S433 | 14,15 |
D21S11 | 31,33.2 |
FGA | 23,24 |
Penta D | 11 |
Penta E | 5,14 |
TH01 | 6,7 |
TPOX | 8 |
vWA | 17,19 |
Run an STR similarity search on this cell line |
Publications | Patent=US4705687 Lau C.Y. Treatment of autoimmune diseases such as rheumatoid arthritis with suppressor factor. Patent number US4705687, 10-Nov-1987 Patent=US4728614 Lau C.Y. Mutant human T cell line producing immunosuppressive factor and method for obtaining such mutants. Patent number US4728614, 01-Mar-1988 |
Cross-references |
Cell line collections (Providers) |
ATCC; CRL-8296 - Discontinued
CLS; 305132
|
Cell line databases/resources |
cancercelllines; CVCL_6869
CCRID; 3101HUMTCHu2
|
Biological sample resources |
BioSample; SAMN03471201
|
Encyclopedic resources |
Wikidata; Q54604612
|
Entry history |
Entry creation | 04-Apr-2012 |
Last entry update | 19-Dec-2024 |
Version number | 31 |
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