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Cellosaurus PC-9/f14 (CVCL_U149)

[Text version]
Cell line name PC-9/f14
Synonyms PC9/f14
Accession CVCL_U149
Resource Identification Initiative To cite this cell line use: PC-9/f14 (RRID:CVCL_U149)
Comments Population: Chinese; Han and Japanese.
Characteristics: Highly metastatic. Established after five additional passages of the parent cell line in nude mice (PubMed=11506965).
Omics: Transcriptome analysis by microarray.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Glu746_Ala750del (c.2235_2249del15); ClinVar=VCV000163343; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_U150 (PC-9/f9)
Sex of cell Male
Age at sampling 45Y
Category Cancer cell line
Publications

PubMed=11506965; DOI=10.1016/S0959-8049(01)00154-X
Gemma A., Takenaka K., Hosoya Y., Matuda K., Seike M., Kurimoto F., Ono Y., Uematsu K., Takeda Y., Hibino S., Yoshimura A., Shibuya M., Kudoh S.
Altered expression of several genes in highly metastatic subpopulations of a human pulmonary adenocarcinoma cell line.
Eur. J. Cancer 37:1554-1561(2001)

PubMed=12696064; DOI=10.1002/gcc.10205
Yoshimura A., Gemma A., Hosoya Y., Komaki E., Hosomi Y., Okano T., Takenaka K., Matuda K., Seike M., Uematsu K., Hibino S., Shibuya M., Yamada T., Hirohashi S., Kudoh S.
Increased expression of the LGALS3 (galectin 3) gene in human non-small-cell lung cancer.
Genes Chromosomes Cancer 37:159-164(2003)

PubMed=17982658; DOI=10.3892/ijo.31.6.1325
Takemura A., Gemma A., Shibuya M., Matsuda K., Okano T., Nara M., Noro R., Minegishi Y., Yoshimura A., Kudoh S.
Gemcitabine resistance in a highly metastatic subpopulation of a pulmonary adenocarcinoma cell line resistant to gefitinib.
Int. J. Oncol. 31:1325-1332(2007)

Cross-references
Cell line databases/resources cancercelllines; CVCL_U149
Encyclopedic resources Wikidata; Q54938492
Polymorphism and mutation databases Cosmic; 915331
Entry history
Entry creation03-Feb-2014
Last entry update19-Dec-2024
Version number18