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Cellosaurus SL0006 (CVCL_TZ90)

[Text version]
Cell line name SL0006
Accession CVCL_TZ90
Resource Identification Initiative To cite this cell line use: SL0006 (RRID:CVCL_TZ90)
Comments Group: Patented cell line.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); PTA-6663.
Population: Caucasian.
Characteristics: Useful for the production of E1-deleted adenovirus (rAd) vectors.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P03255; Adenovirus 5 E1A protein (Note=With p.Ile4_Glu25del and p.Ser111_Thr123del = dl01/07).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P03243; Adenovirus 5 E1B 55 kDa protein.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P03246; Adenovirus 5 E1B 19 kDa protein.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P04495; Adenovirus 5 DNA polymerase.
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Ser (c.34G>A); ClinVar=VCV000012584; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0023 (A-549)
Sex of cell Male
Age at sampling 58Y
Category Cancer cell line
Publications

PubMed=16246392; DOI=10.1016/j.virol.2005.09.029
Howe J.A., Pelka P., Antelman D., Wilson C., Cornell D., Hancock W., Ramachandra M., Avanzini J., Horn M., Wills K.N., Sutjipto S., Ralston R.O. 2nd
Matching complementing functions of transformed cells with stable expression of selected viral genes for production of E1-deleted adenovirus vectors.
Virology 345:220-230(2006)

Patent=US7851218
Howe J.A., Wills K.N., Ralston R.O. 2nd, Sherrill S.J.
Cell lines for production of replication-defective adenovirus.
Patent number US7851218, 14-Dec-2010

Cross-references
Cell line databases/resources cancercelllines; CVCL_TZ90
Encyclopedic resources Wikidata; Q54954829
Entry history
Entry creation14-May-2018
Last entry update19-Dec-2024
Version number13