ID   SL0006
AC   CVCL_TZ90
DR   ATCC; PTA-6663
DR   cancercelllines; CVCL_TZ90
DR   Wikidata; Q54954829
RX   Patent=US7851218;
RX   PubMed=16246392;
CC   Group: Patented cell line.
CC   Registration: International Depositary Authority, American Type Culture Collection (ATCC); PTA-6663.
CC   Population: Caucasian.
CC   Characteristics: Useful for the production of E1-deleted adenovirus (rAd) vectors.
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Ser (c.34G>A); ClinVar=VCV000012584; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
CC   Transfected with: UniProtKB; P03255; Adenovirus 5 E1A protein (with p.Ile4_Glu25del and p.Ser111_Thr123del = dl01/07).
CC   Transfected with: UniProtKB; P03243; Adenovirus 5 E1B 55 kDa protein.
CC   Transfected with: UniProtKB; P03246; Adenovirus 5 E1B 19 kDa protein.
CC   Transfected with: UniProtKB; P04495; Adenovirus 5 DNA polymerase.
CC   Derived from site: In situ; Lung; UBERON=UBERON_0002048.
DI   NCIt; C3512; Lung adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0023 ! A-549
SX   Male
AG   58Y
CA   Cancer cell line
DT   Created: 14-05-18; Last updated: 05-10-23; Version: 10
//
RX   Patent=US7851218;
RA   Howe J.A., Wills K.N., Ralston R.O. II, Sherrill S.J.;
RT   "Cell lines for production of replication-defective adenovirus.";
RL   Patent number US7851218, 14-Dec-2010.
//
RX   PubMed=16246392; DOI=10.1016/j.virol.2005.09.029;
RA   Howe J.A., Pelka P., Antelman D., Wilson C., Cornell D., Hancock W.,
RA   Ramachandra M., Avanzini J., Horn M., Wills K.N., Sutjipto S.,
RA   Ralston R.O. II;
RT   "Matching complementing functions of transformed cells with stable
RT   expression of selected viral genes for production of E1-deleted
RT   adenovirus vectors.";
RL   Virology 345:220-230(2006).
//