• Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  
• Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg156Pro (c.467G>C); ClinVar=VCV000634768; Zygosity=Homozygous (from parent cell line).
  

PubMed=17096323; DOI=10.1002/ijc.22327
Lourda M., Trougakos I.P., Gonos E.S.
Development of resistance to chemotherapeutic drugs in human osteosarcoma cell lines largely depends on up-regulation of clusterin/apolipoprotein J.
Int. J. Cancer 120:611-622(2007)

PubMed=19638450; DOI=10.1158/1535-7163.MCT-09-0115; PMCID=PMC2766237
Duan Z.-F., Choy E., Harmon D.C., Yang C., Ryu K., Schwab J.H., Mankin H.J., Hornicek F.J.
Insulin-like growth factor-I receptor tyrosine kinase inhibitor cyclolignan picropodophyllin inhibits proliferation and induces apoptosis in multidrug resistant osteosarcoma cell lines.
Mol. Cancer Ther. 8:2122-2130(2009)

PubMed=24866169; DOI=10.1158/2326-6066.CIR-13-0224; PMCID=PMC4082476
Shen J.K., Cote G.M., Choy E., Yang P., Harmon D.C., Schwab J.H., Nielsen G.P., Chebib I., Ferrone S., Wang X.-H., Wang Y.-Y., Mankin H.J., Hornicek F.J., Duan Z.-F.
Programmed cell death ligand 1 expression in osteosarcoma.
Cancer Immunol. Res. 2:690-698(2014)

PubMed=25236161; DOI=10.1186/1471-2407-14-681; PMCID=PMC4177239
Duan Z.-F., Zhang J.-M., Ye S.-N., Shen J.K., Choy E., Cote G.M., Harmon D.C., Mankin H.J., Hua Y.-Q., Zhang Y., Gray N.S., Hornicek F.J.
A-770041 reverses paclitaxel and doxorubicin resistance in osteosarcoma cells.
BMC Cancer 14:681.1-681.11(2014)