ID   KH OS R2
AC   CVCL_T432
SY   KHOSR2; KHOS(R2); KHOS R2; KHOSMR
DR   cancercelllines; CVCL_T432
DR   Wikidata; Q54899847
RX   PubMed=17096323;
RX   PubMed=19638450;
RX   PubMed=24866169;
RX   PubMed=25236161;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI:28748; Doxorubicin (Adriablastin; Adriamycin).
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg156Pro (c.467G>C); ClinVar=VCV000634768; Zygosity=Homozygous (from parent cell line).
CC   Transformant: NCBI_TaxID; 11808; Kirsten murine sarcoma virus (Ki-MSV).
CC   Derived from site: In situ; Bone, right femur; UBERON=UBERON_0000981.
DI   NCIt; C9145; Osteosarcoma
DI   ORDO; Orphanet_668; Osteosarcoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_T431 ! KH OS R1
SX   Female
AG   13Y
CA   Cancer cell line
DT   Created: 03-02-14; Last updated: 05-10-23; Version: 15
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RX   PubMed=17096323; DOI=10.1002/ijc.22327;
RA   Lourda M., Trougakos I.P., Gonos E.S.;
RT   "Development of resistance to chemotherapeutic drugs in human
RT   osteosarcoma cell lines largely depends on up-regulation of
RT   clusterin/apolipoprotein J.";
RL   Int. J. Cancer 120:611-622(2007).
//
RX   PubMed=19638450; DOI=10.1158/1535-7163.MCT-09-0115; PMCID=PMC2766237;
RA   Duan Z.-F., Choy E., Harmon D.C., Yang C., Ryu K., Schwab J.H.,
RA   Mankin H.J., Hornicek F.J.;
RT   "Insulin-like growth factor-I receptor tyrosine kinase inhibitor
RT   cyclolignan picropodophyllin inhibits proliferation and induces
RT   apoptosis in multidrug resistant osteosarcoma cell lines.";
RL   Mol. Cancer Ther. 8:2122-2130(2009).
//
RX   PubMed=24866169; DOI=10.1158/2326-6066.CIR-13-0224; PMCID=PMC4082476;
RA   Shen J.K., Cote G.M., Choy E., Yang P., Harmon D.C., Schwab J.H.,
RA   Nielsen G.P., Chebib I., Ferrone S., Wang X.-H., Wang Y.-Y.,
RA   Mankin H.J., Hornicek F.J., Duan Z.-F.;
RT   "Programmed cell death ligand 1 expression in osteosarcoma.";
RL   Cancer Immunol. Res. 2:690-698(2014).
//
RX   PubMed=25236161; DOI=10.1186/1471-2407-14-681; PMCID=PMC4177239;
RA   Duan Z.-F., Zhang J.-M., Ye S.-N., Shen J.K., Choy E., Cote G.M.,
RA   Harmon D.C., Mankin H.J., Hua Y.-Q., Zhang Y., Gray N.S., Hornicek F.J.;
RT   "A-770041 reverses paclitaxel and doxorubicin resistance in
RT   osteosarcoma cells.";
RL   BMC Cancer 14:681.1-681.11(2014).
//