Cellosaurus cell line HSC-GRW (CVCL

Cross-references
Cell line name	HSC-GRW
Accession	CVCL_S965
Resource Identification Initiative	To cite this cell line use: HSC-GRW (RRID:CVCL_S965)
Comments	Characteristics: KITLG dependent.
Sequence variations	Mutation; HGNC; HGNC:4170; GATA1; Simple; p.Pro50fs*6 (c.150_184del35); Zygosity=Unspecified (PubMed=12586620).
Disease	Down syndrome (NCIt: C2993) Myeloid leukemia associated with Down syndrome (NCIt: C43223) Down syndrome (ORDO: Orphanet_870) Acute megakaryoblastic leukemia in Down syndrome (ORDO: Orphanet_99887)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Sex unspecified
Age at sampling	Age unspecified
Category	Cancer cell line
Publications	CLPUB00052 Zipursky A., Vanek W., Grunberger T., Brown E.J., Wang H., Sutherland D.R., Yeo E.L., Cohen A., Christensen H., Freedman M.H. A megakaryoblast cell line from a patient with Down syndrome-acute megakaryoblastic leukemia (DS-AMKL): in vitro differentiation of megakaryoblasts. Blood 82 Suppl. 1:122a-122a(1993) PubMed=12586620; DOI=10.1182/blood-2003-01-0013 Hitzler J.K., Cheung J., Li Y., Scherer S.W., Zipursky A. GATA1 mutations in transient leukemia and acute megakaryoblastic leukemia of Down syndrome. Blood 101:4301-4304(2003)
Encyclopedic resources	Wikidata; Q54896415
Polymorphism and mutation databases	Cosmic; 977943
Entry history
Entry creation	03-Feb-2014
Last entry update	19-Dec-2024
Version number	10