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Cellosaurus PC-6/SN2-5 (CVCL_S850)

[Text version]
Cell line name PC-6/SN2-5
Accession CVCL_S850
Resource Identification Initiative To cite this cell line use: PC-6/SN2-5 (RRID:CVCL_S850)
Comments Population: Japanese.
Selected for resistance to: ChEBI; CHEBI:8988; SN-38 (7-ethyl-10-hydroxy-camptothecin).
Disease Lung small cell carcinoma (NCIt: C4917)
Small cell lung cancer (ORDO: Orphanet_70573)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_C002 (PC-6)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=9259410; DOI=10.1002/(SICI)1097-0215(19970807)72:4<680::AID-IJC21>3.0.CO;2-E
Joto N., Ishii M., Minami M., Kuga H., Mitsui I., Tohgo A.
DX-8951f, a water-soluble camptothecin analog, exhibits potent antitumor activity against a human lung cancer cell line and its SN-38-resistant variant.
Int. J. Cancer 72:680-686(1997)

PubMed=10912951; DOI=10.1097/00001813-200006000-00005
Ishii M., Iwahana M., Mitsui I., Minami M., Imagawa S., Tohgo A., Ejima A.
Growth inhibitory effect of a new camptothecin analog, DX-8951f, on various drug-resistant sublines including BCRP-mediated camptothecin derivative-resistant variants derived from the human lung cancer cell line PC-6.
Anticancer Drugs 11:353-362(2000)

PubMed=17237272; DOI=10.1158/1535-7163.MCT-06-0529
Oguri T., Bessho Y., Achiwa H., Ozasa H., Maeno K., Maeda H., Sato S., Ueda R.
MRP8/ABCC11 directly confers resistance to 5-fluorouracil.
Mol. Cancer Ther. 6:122-127(2007)

Cross-references
Encyclopedic resources Wikidata; Q54938462
Entry history
Entry creation03-Feb-2014
Last entry update21-Mar-2023
Version number9