ID   PC-6/SN2-5
AC   CVCL_S850
DR   Wikidata; Q54938462
RX   PubMed=9259410;
RX   PubMed=10912951;
RX   PubMed=17237272;
CC   Population: Japanese.
CC   Selected for resistance to: ChEBI; CHEBI_8988; SN-38 (7-ethyl-10-hydroxy-camptothecin).
DI   NCIt; C4917; Lung small cell carcinoma
DI   ORDO; Orphanet_70573; Small cell lung cancer
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_C002 ! PC-6
SX   Sex unspecified
AG   Age unspecified
CA   Cancer cell line
DT   Created: 03-02-14; Last updated: 19-12-24; Version: 10
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RX   PubMed=10912951; DOI=10.1097/00001813-200006000-00005;
RA   Ishii, Mineko
RA   Iwahana, Michio
RA   Mitsui, Ikuo
RA   Minami, Megumi
RA   Imagawa, Setsuko
RA   Tohgo, Akiko
RA   Ejima, Akio
RT   "Growth inhibitory effect of a new camptothecin analog, DX-8951f, on
RT   various drug-resistant sublines including BCRP-mediated camptothecin
RT   derivative-resistant variants derived from the human lung cancer cell
RT   line PC-6.";
RL   Anticancer Drugs 11:353-362(2000).
//
RX   PubMed=17237272; DOI=10.1158/1535-7163.MCT-06-0529;
RA   Oguri, Tetsuya
RA   Bessho, Yuji
RA   Achiwa, Hiroyuki
RA   Ozasa, Hiroaki
RA   Maeno, Ken
RA   Maeda, Hiroyoshi
RA   Sato, Shigeki
RA   Ueda, Ryuzo
RT   "MRP8/ABCC11 directly confers resistance to 5-fluorouracil.";
RL   Mol. Cancer Ther. 6:122-127(2007).
//
RX   PubMed=9259410; DOI=10.1002/(SICI)1097-0215(19970807)72:4<680::AID-IJC21>3.0.CO;2-E;
RA   Joto, Noriko
RA   Ishii, Mineko
RA   Minami, Megumi
RA   Kuga, Hiroshi
RA   Mitsui, Ikuo
RA   Tohgo, Akiko
RT   "DX-8951f, a water-soluble camptothecin analog, exhibits potent
RT   antitumor activity against a human lung cancer cell line and its
RT   SN-38-resistant variant.";
RL   Int. J. Cancer 72:680-686(1997).
//