ID   PC-6/SN2-5
AC   CVCL_S850
DR   Wikidata; Q54938462
RX   PubMed=9259410;
RX   PubMed=10912951;
RX   PubMed=17237272;
CC   Population: Japanese.
CC   Selected for resistance to: ChEBI; CHEBI:8988; SN-38 (7-ethyl-10-hydroxy-camptothecin).
DI   NCIt; C4917; Lung small cell carcinoma
DI   ORDO; Orphanet_70573; Small cell lung cancer
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_C002 ! PC-6
SX   Sex unspecified
AG   Age unspecified
CA   Cancer cell line
DT   Created: 03-02-14; Last updated: 21-03-23; Version: 9
//
RX   PubMed=9259410; DOI=10.1002/(SICI)1097-0215(19970807)72:4<680::AID-IJC21>3.0.CO;2-E;
RA   Joto N., Ishii M., Minami M., Kuga H., Mitsui I., Tohgo A.;
RT   "DX-8951f, a water-soluble camptothecin analog, exhibits potent
RT   antitumor activity against a human lung cancer cell line and its
RT   SN-38-resistant variant.";
RL   Int. J. Cancer 72:680-686(1997).
//
RX   PubMed=10912951; DOI=10.1097/00001813-200006000-00005;
RA   Ishii M., Iwahana M., Mitsui I., Minami M., Imagawa S., Tohgo A.,
RA   Ejima A.;
RT   "Growth inhibitory effect of a new camptothecin analog, DX-8951f, on
RT   various drug-resistant sublines including BCRP-mediated camptothecin
RT   derivative-resistant variants derived from the human lung cancer cell
RT   line PC-6.";
RL   Anticancer Drugs 11:353-362(2000).
//
RX   PubMed=17237272; DOI=10.1158/1535-7163.MCT-06-0529;
RA   Oguri T., Bessho Y., Achiwa H., Ozasa H., Maeno K., Maeda H., Sato S.,
RA   Ueda R.;
RT   "MRP8/ABCC11 directly confers resistance to 5-fluorouracil.";
RL   Mol. Cancer Ther. 6:122-127(2007).
//