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Cellosaurus ORL-136 (CVCL_S691)

[Text version]
Cell line name ORL-136
Synonyms ORL-136T; 136T
Accession CVCL_S691
Resource Identification Initiative To cite this cell line use: ORL-136 (RRID:CVCL_S691)
Comments Population: Indian.
Microsatellite instability: Stable (MSS) (PubMed=17273794).
Omics: CRISPR phenotypic screen.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Oral cavity, tongue; UBERON=UBERON_0001723.
Sequence variations
Disease Tongue squamous cell carcinoma (NCIt: C4648)
Squamous cell carcinoma of the oral tongue (ORDO: Orphanet_457252)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 57Y
Category Cancer cell line
STR profile Source(s): PubMed=27050151

Markers:
AmelogeninX,Y
CSF1PO8,11
D2S133819,22
D3S135815,16
D5S81810
D7S8209,12
D8S117914,16
D13S3178,9
D16S5399,12
D18S5114,15
D19S43312,16
D21S1129.2,32.2
FGA22
TH016,9
TPOX9,10
vWA16,18

Run an STR similarity search on this cell line
Publications

PubMed=17273794; DOI=10.3892/ijmm.19.3.453
Hamid S., Lim K.P., Zain R.B., Ismail S.M., Lau S.H., Mustafa W.M.W., Abraham M.T., Nam N.A., Teo S.-H., Cheong S.-C.
Establishment and characterization of Asian oral cancer cell lines as in vitro models to study a disease prevalent in Asia.
Int. J. Mol. Med. 19:453-460(2007)

PubMed=24224046; DOI=10.1371/journal.pone.0080229; PMCID=PMC3817115
Zanaruddin S.N.S., Yee P.-S., Hor S.Y., Kong Y.H., Ghani W.M.N.W.A., Mustafa W.M.W., Zain R.B., Prime S.S., Rahman Z.A.A., Cheong S.-C.
Common oncogenic mutations are infrequent in oral squamous cell carcinoma of Asian origin.
PLoS ONE 8:E80229-E80229(2013)

PubMed=27050151; DOI=10.18632/oncotarget.8533; PMCID=PMC5053689
Fadlullah M.Z.H., Chiang I.K.-N., Dionne K.R., Yee P.-S., Gan C.P., Sam K.K., Tiong K.H., Ng A.K.W., Martin D., Lim K.P., Kallarakkal T.G., Mustafa W.M.W., Lau S.H., Abraham M.T., Zain R.B., Rahman Z.A.A., Molinolo A.A., Patel V., Gutkind J.S., Tan A.-C., Cheong S.-C.
Genetically-defined novel oral squamous cell carcinoma cell lines for the development of molecular therapies.
Oncotarget 7:27802-27818(2016)

PubMed=32990596; DOI=10.7554/eLife.57761; PMCID=PMC7591259
Chai A.W.-Y., Yee P.-S., Price S., Yee S.-M., Lee H.-M., Tiong V.K.H., Goncalves E., Behan F.M., Bateson J., Gilbert J.G.R., Tan A.-C., McDermott U., Garnett M.J., Cheong S.-C.
Genome-wide CRISPR screens of oral squamous cell carcinoma reveal fitness genes in the Hippo pathway.
eLife 9:e57761.1-e57761.34(2020)

Cross-references
Cell line databases/resources Cell_Model_Passport; SIDM02006
CRISP screens repositories BioGRID_ORCS_Cell_line; 1272
Encyclopedic resources Wikidata; Q54936491
Polymorphism and mutation databases Cosmic; 2531648
Cosmic; 2559736
IARC_TP53; 25071
Entry history
Entry creation03-Feb-2014
Last entry update19-Dec-2024
Version number17