ID   ORL-136
AC   CVCL_S691
SY   ORL-136T; 136T
DR   BioGRID_ORCS_Cell_line; 1272
DR   Cell_Model_Passport; SIDM02006
DR   Cosmic; 2531648
DR   Cosmic; 2559736
DR   IARC_TP53; 25071
DR   Wikidata; Q54936491
RX   PubMed=17273794;
RX   PubMed=24224046;
RX   PubMed=27050151;
RX   PubMed=32990596;
CC   Population: Indian.
CC   Microsatellite instability: Stable (MSS) (PubMed=17273794).
CC   Sequence variation: Mutation; HGNC; HGNC:3595; FAT1; Simple; p.Gln3585Ter (c.10753C>T); Zygosity=Unspecified (PubMed=27050151).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Cys176Phe (c.527G>T); ClinVar=VCV000376569; Zygosity=Unspecified (PubMed=17273794; PubMed=24224046; PubMed=27050151).
CC   Omics: CRISPR phenotypic screen.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Derived from site: In situ; Oral cavity, tongue; UBERON=UBERON_0001723.
ST   Source(s): PubMed=27050151
ST   Amelogenin: X,Y
ST   CSF1PO: 8,11
ST   D13S317: 8,9
ST   D16S539: 9,12
ST   D18S51: 14,15
ST   D19S433: 12,16
ST   D21S11: 29.2,32.2
ST   D2S1338: 19,22
ST   D3S1358: 15,16
ST   D5S818: 10
ST   D7S820: 9,12
ST   D8S1179: 14,16
ST   FGA: 22
ST   TH01: 6,9
ST   TPOX: 9,10
ST   vWA: 16,18
DI   NCIt; C4648; Tongue squamous cell carcinoma
DI   ORDO; Orphanet_457252; Squamous cell carcinoma of the oral tongue
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   57Y
CA   Cancer cell line
DT   Created: 03-02-14; Last updated: 19-12-24; Version: 17
//
RX   PubMed=17273794; DOI=10.3892/ijmm.19.3.453;
RA   Hamid S., Lim K.P., Zain R.B., Ismail S.M., Lau S.H., Mustafa W.M.W.,
RA   Abraham M.T., Nam N.A., Teo S.-H., Cheong S.-C.;
RT   "Establishment and characterization of Asian oral cancer cell lines as
RT   in vitro models to study a disease prevalent in Asia.";
RL   Int. J. Mol. Med. 19:453-460(2007).
//
RX   PubMed=24224046; DOI=10.1371/journal.pone.0080229; PMCID=PMC3817115;
RA   Zanaruddin S.N.S., Yee P.-S., Hor S.Y., Kong Y.H., Ghani W.M.N.W.A.,
RA   Mustafa W.M.W., Zain R.B., Prime S.S., Rahman Z.A.A., Cheong S.-C.;
RT   "Common oncogenic mutations are infrequent in oral squamous cell
RT   carcinoma of Asian origin.";
RL   PLoS ONE 8:E80229-E80229(2013).
//
RX   PubMed=27050151; DOI=10.18632/oncotarget.8533; PMCID=PMC5053689;
RA   Fadlullah M.Z.H., Chiang I.K.-N., Dionne K.R., Yee P.-S., Gan C.P.,
RA   Sam K.K., Tiong K.H., Ng A.K.W., Martin D., Lim K.P., Kallarakkal T.G.,
RA   Mustafa W.M.W., Lau S.H., Abraham M.T., Zain R.B., Rahman Z.A.A.,
RA   Molinolo A.A., Patel V., Gutkind J.S., Tan A.-C., Cheong S.-C.;
RT   "Genetically-defined novel oral squamous cell carcinoma cell lines for
RT   the development of molecular therapies.";
RL   Oncotarget 7:27802-27818(2016).
//
RX   PubMed=32990596; DOI=10.7554/eLife.57761; PMCID=PMC7591259;
RA   Chai A.W.-Y., Yee P.-S., Price S., Yee S.-M., Lee H.-M., Tiong V.K.H.,
RA   Goncalves E., Behan F.M., Bateson J., Gilbert J.G.R., Tan A.-C.,
RA   McDermott U., Garnett M.J., Cheong S.-C.;
RT   "Genome-wide CRISPR screens of oral squamous cell carcinoma reveal
RT   fitness genes in the Hippo pathway.";
RL   eLife 9:e57761.1-e57761.34(2020).
//