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Cellosaurus Ma-Mel-61c (CVCL_S666)

[Text version]
Cell line name Ma-Mel-61c
Accession CVCL_S666
Resource Identification Initiative To cite this cell line use: Ma-Mel-61c (RRID:CVCL_S666)
Comments Omics: SNP array analysis.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations
  • Gene deletion; HGNC; 6190; JAK1; Zygosity=Heterozygous (PubMed=28561041).
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (PubMed=23348503).
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_C291 ! Ma-Mel-61a
CVCL_C292 ! Ma-Mel-61b
CVCL_S667 ! Ma-Mel-61e
CVCL_S668 ! Ma-Mel-61f
CVCL_S669 ! Ma-Mel-61g
CVCL_S670 ! Ma-Mel-61h
Sex of cell Male
Age at sampling 29Y
Category Cancer cell line
Publications

PubMed=23348503; DOI=10.1126/science.1230062
Horn S., Figl A., Rachakonda P.S., Fischer C., Sucker A., Gast A., Kadel S., Moll I., Nagore E., Hemminki K., Schadendorf D., Kumar R.
TERT promoter mutations in familial and sporadic melanoma.
Science 339:959-961(2013)

PubMed=28561041; DOI=10.1038/ncomms15440; PMCID=PMC5460020
Sucker A., Zhao F., Pieper N., Heeke C., Maltaner R., Stadtler N., Real B., Bielefeld N., Howe S., Weide B., Gutzmer R., Utikal J.S., Loquai C., Gogas H., Klein-Hitpass L., Zeschnigk M., Westendorf A.M., Trilling M., Horn S., Schilling B., Schadendorf D., Griewank K.G., Paschen A.
Acquired IFNgamma resistance impairs anti-tumor immunity and gives rise to T-cell-resistant melanoma lesions.
Nat. Commun. 8:15440.1-15440.15(2017)

Cross-references
Cell line databases/resources cancercelllines; CVCL_S666
Encyclopedic resources Wikidata; Q54903830
Gene expression databases GEO; GSM2545595
Polymorphism and mutation databases Cosmic; 2686448
Progenetix; CVCL_S666
Entry history
Entry creation03-Feb-2014
Last entry update10-Sep-2024
Version number12