Cellosaurus cell line Ma-Mel-61c (CVCL

Cellosaurus Ma-Mel-61c (CVCL_S666)

Cross-references
Cell line name	Ma-Mel-61c
Accession	CVCL_S666
Resource Identification Initiative	To cite this cell line use: Ma-Mel-61c (RRID:CVCL_S666)
Comments	Omics: SNP array analysis. Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations	Gene deletion; HGNC; HGNC:6190; JAK1; Zygosity=Heterozygous (PubMed=28561041). Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (PubMed=23348503).
Disease	Melanoma (NCIt: C3224)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual	CVCL_C291 ! Ma-Mel-61a CVCL_C292 ! Ma-Mel-61b CVCL_S667 ! Ma-Mel-61e CVCL_S668 ! Ma-Mel-61f CVCL_S669 ! Ma-Mel-61g CVCL_S670 ! Ma-Mel-61h
Sex of cell	Male
Age at sampling	29Y
Category	Cancer cell line
Publications	PubMed=23348503; DOI=10.1126/science.1230062 Horn S., Figl A., Rachakonda P.S., Fischer C., Sucker A., Gast A., Kadel S., Moll I., Nagore E., Hemminki K., Schadendorf D., Kumar R. TERT promoter mutations in familial and sporadic melanoma. Science 339:959-961(2013) PubMed=28561041; DOI=10.1038/ncomms15440; PMCID=PMC5460020 Sucker A., Zhao F., Pieper N., Heeke C., Maltaner R., Stadtler N., Real B., Bielefeld N., Howe S., Weide B., Gutzmer R., Utikal J.S., Loquai C., Gogas H., Klein-Hitpass L., Zeschnigk M., Westendorf A.M., Trilling M., Horn S., Schilling B., Schadendorf D., Griewank K.G., Paschen A. Acquired IFNgamma resistance impairs anti-tumor immunity and gives rise to T-cell-resistant melanoma lesions. Nat. Commun. 8:15440.1-15440.15(2017)
Cell line databases/resources	cancercelllines; CVCL_S666
Encyclopedic resources	Wikidata; Q54903830
Gene expression databases	GEO; GSM2545595
Polymorphism and mutation databases	Cosmic; 2686448 Progenetix; CVCL_S666
Entry history
Entry creation	03-Feb-2014
Last entry update	19-Dec-2024
Version number	13