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Cellosaurus Ma-Mel-61b (CVCL_C292)

[Text version]
Cell line name Ma-Mel-61b
Synonyms MaMel61b
Accession CVCL_C292
Resource Identification Initiative To cite this cell line use: Ma-Mel-61b (RRID:CVCL_C292)
Comments Omics: SNP array analysis.
Derived from site: Metastatic; Cutaneous; UBERON=UBERON_0000014.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Heterozygous (PubMed=26909863).
  • Gene deletion; HGNC; 1788; CDKN2B; Zygosity=Heterozygous (PubMed=26909863).
  • Gene deletion; HGNC; 6190; JAK1; Zygosity=Heterozygous (PubMed=28561041).
  • Gene fusion; HGNC; 7413; MTAP + HGNC; 34341; CDKN2B-AS1; Name(s)=MTAP-ANRIL (PubMed=26909863).
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (PubMed=23348503).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (PubMed=23348503).
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_C291 ! Ma-Mel-61a
CVCL_S666 ! Ma-Mel-61c
CVCL_S667 ! Ma-Mel-61e
CVCL_S668 ! Ma-Mel-61f
CVCL_S669 ! Ma-Mel-61g
CVCL_S670 ! Ma-Mel-61h
Sex of cell Male
Age at sampling 29Y
Category Cancer cell line
STR profile Source(s): ESTDAB=ESTDAB-219

Markers:
AmelogeninX,Y
CSF1PO11
D3S135816
D5S81811
D7S82012
D13S3179,12
FGA20
TH019,9.3
TPOX8
vWA16,17

Run an STR similarity search on this cell line
Publications

PubMed=23348503; DOI=10.1126/science.1230062
Horn S., Figl A., Rachakonda P.S., Fischer C., Sucker A., Gast A., Kadel S., Moll I., Nagore E., Hemminki K., Schadendorf D., Kumar R.
TERT promoter mutations in familial and sporadic melanoma.
Science 339:959-961(2013)

PubMed=26909863; DOI=10.18632/oncotarget.7503; PMCID=PMC4941330
Xie H.-P., Rachakonda P.S., Heidenreich B., Nagore E., Sucker A., Hemminki K., Schadendorf D., Kumar R.
Mapping of deletion breakpoints at the CDKN2A locus in melanoma: detection of MTAP-ANRIL fusion transcripts.
Oncotarget 7:16490-16504(2016)

PubMed=28561041; DOI=10.1038/ncomms15440; PMCID=PMC5460020
Sucker A., Zhao F., Pieper N., Heeke C., Maltaner R., Stadtler N., Real B., Bielefeld N., Howe S., Weide B., Gutzmer R., Utikal J.S., Loquai C., Gogas H., Klein-Hitpass L., Zeschnigk M., Westendorf A.M., Trilling M., Horn S., Schilling B., Schadendorf D., Griewank K.G., Paschen A.
Acquired IFNgamma resistance impairs anti-tumor immunity and gives rise to T-cell-resistant melanoma lesions.
Nat. Commun. 8:15440.1-15440.15(2017)

Cross-references
Cell line databases/resources cancercelllines; CVCL_C292
ESTDAB; ESTDAB-219
Encyclopedic resources Wikidata; Q54903829
Gene expression databases GEO; GSM2545594
Polymorphism and mutation databases Cosmic; 1846649
Cosmic; 2686446
Progenetix; CVCL_C292
Entry history
Entry creation22-Oct-2012
Last entry update02-May-2024
Version number16