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Cellosaurus SKK-1 (CVCL_S607)

[Text version]
Cell line name SKK-1
Synonyms SKK1
Accession CVCL_S607
Resource Identification Initiative To cite this cell line use: SKK-1 (RRID:CVCL_S607)
Comments Population: Japanese.
Doubling time: 32 hours (PubMed=15996938).
Karyotypic information: Has a chromosome 8 trisomy. 47,XY,add(4)(p16),+8,add(12)(p13) (PubMed=15996938).
Omics: SNP array analysis.
Miscellaneous: STR profile from personal communication of Diesch, Jeannine.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
Disease Adult acute myeloid leukemia (NCIt: C9154)
Myelodysplastic syndrome (NCIt: C3247)
Acute myeloid leukemia (ORDO: Orphanet_519)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 69Y
Category Cancer cell line
STR profile Source(s): Direct_author_submission

Markers:
AmelogeninX,Y
CSF1PO11,12
D2S133819,20
D3S135816,17
D5S81812
D7S82011,12
D8S117912,13
D13S31710
D16S5399,11
D18S5113,14
D19S43312,14
D21S1129,32
FGA21,23
TH019
TPOX9,11
vWA14,16

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Publications

PubMed=15996938
Matsuoka H., Murayama T., Koizumi T., Nishimura R., Kawaguchi R., Nakagawa T.
Establishment of a human myeloid cell line with trisomy 8 derived from overt leukemia following myelodysplastic syndrome.
Haematologica 90:981-982(2005)

PubMed=27750403; DOI=10.1002/gcc.22430
Palau A., Mallo M., Palomo L., Rodriguez-Hernandez I., Diesch J., Campos D., Granada I., Junca J., Drexler H.G., Sole F., Buschbeck M.
Immunophenotypic, cytogenetic, and mutational characterization of cell lines derived from myelodysplastic syndrome patients after progression to acute myeloid leukemia.
Genes Chromosomes Cancer 56:243-252(2017)

PubMed=28751768; DOI=10.1038/leu.2017.240; PMCID=PMC5630086
Jawhar M., Naumann N., Knut M., Score J., Ghazzawi M.A.M., Schneider B., Kreuzer K.-A., Hallek M., Drexler H.G., Chacko J., Wallis L., Fabarius A., Metzgeroth G., Hofmann W.-K., Chase A., Tapper W.J., Reiter A., Cross N.C.P.
Cytogenetically cryptic ZMYM2-FLT3 and DIAPH1-PDGFRB gene fusions in myeloid neoplasms with eosinophilia.
Leukemia 31:2271-2273(2017)

PubMed=34707142; DOI=10.1038/s41598-021-00623-w; PMCID=PMC8551338
Maher M., Diesch J., Le Pannerer M.-M., Cabezon M., Mallo M., Vergara S., Mendez Lopez A., Mesa Tudel A., Sole F., Sorigue M., Zamora L., Granada I., Buschbeck M.
Divergent leukaemia subclones as cellular models for testing vulnerabilities associated with gains in chromosomes 7, 8 or 18.
Sci. Rep. 11:21145-21145(2021)

Cross-references
Cell line databases/resources cancercelllines; CVCL_S607
Encyclopedic resources Wikidata; Q54954745
Gene expression databases GEO; GSM2124118
Polymorphism and mutation databases Cosmic; 1465963
Progenetix; CVCL_S607
Entry history
Entry creation03-Feb-2014
Last entry update19-Dec-2024
Version number16