ID   SKK-1
AC   CVCL_S607
SY   SKK1
DR   cancercelllines; CVCL_S607
DR   Cosmic; 1465963
DR   GEO; GSM2124118
DR   Progenetix; CVCL_S607
DR   Wikidata; Q54954745
RX   PubMed=15996938;
RX   PubMed=27750403;
RX   PubMed=28751768;
RX   PubMed=34707142;
CC   Population: Japanese.
CC   Doubling time: 32 hours (PubMed=15996938).
CC   Karyotypic information: Has a chromosome 8 trisomy. 47,XY,add(4)(p16),+8,add(12)(p13) (PubMed=15996938).
CC   Sequence variation: Gene fusion; HGNC; HGNC:3495; ETV6 + HGNC; HGNC:8033; NTRK3; Name(s)=ETV6-NTRK3, TEL-TRKC; Note=In frame (PubMed=28751768; PubMed=34707142).
CC   Sequence variation: Mutation; HGNC; HGNC:12453; U2AF1; Simple; p.Ser34Phe (c.101C>T); ClinVar=VCV000376025; Zygosity=Heterozygous (PubMed=27750403).
CC   Omics: SNP array analysis.
CC   Miscellaneous: STR profile from personal communication of Diesch, Jeannine.
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
ST   Source(s): Direct_author_submission
ST   Amelogenin: X,Y
ST   CSF1PO: 11,12
ST   D13S317: 10
ST   D16S539: 9,11
ST   D18S51: 13,14
ST   D19S433: 12,14
ST   D21S11: 29,32
ST   D2S1338: 19,20
ST   D3S1358: 16,17
ST   D5S818: 12
ST   D7S820: 11,12
ST   D8S1179: 12,13
ST   FGA: 21,23
ST   TH01: 9
ST   TPOX: 9,11
ST   vWA: 14,16
DI   NCIt; C9154; Adult acute myeloid leukemia
DI   NCIt; C3247; Myelodysplastic syndrome
DI   ORDO; Orphanet_519; Acute myeloid leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   69Y
CA   Cancer cell line
DT   Created: 03-02-14; Last updated: 19-12-24; Version: 16
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RX   PubMed=15996938;
RA   Matsuoka H., Murayama T., Koizumi T., Nishimura R., Kawaguchi R.,
RA   Nakagawa T.;
RT   "Establishment of a human myeloid cell line with trisomy 8 derived
RT   from overt leukemia following myelodysplastic syndrome.";
RL   Haematologica 90:981-982(2005).
//
RX   PubMed=27750403; DOI=10.1002/gcc.22430;
RA   Palau A., Mallo M., Palomo L., Rodriguez-Hernandez I., Diesch J.,
RA   Campos D., Granada I., Junca J., Drexler H.G., Sole F., Buschbeck M.;
RT   "Immunophenotypic, cytogenetic, and mutational characterization of
RT   cell lines derived from myelodysplastic syndrome patients after
RT   progression to acute myeloid leukemia.";
RL   Genes Chromosomes Cancer 56:243-252(2017).
//
RX   PubMed=28751768; DOI=10.1038/leu.2017.240; PMCID=PMC5630086;
RA   Jawhar M., Naumann N., Knut M., Score J., Ghazzawi M.A.M.,
RA   Schneider B., Kreuzer K.-A., Hallek M., Drexler H.G., Chacko J.,
RA   Wallis L., Fabarius A., Metzgeroth G., Hofmann W.-K., Chase A.,
RA   Tapper W.J., Reiter A., Cross N.C.P.;
RT   "Cytogenetically cryptic ZMYM2-FLT3 and DIAPH1-PDGFRB gene fusions in
RT   myeloid neoplasms with eosinophilia.";
RL   Leukemia 31:2271-2273(2017).
//
RX   PubMed=34707142; DOI=10.1038/s41598-021-00623-w; PMCID=PMC8551338;
RA   Maher M., Diesch J., Le Pannerer M.-M., Cabezon M., Mallo M.,
RA   Vergara S., Mendez Lopez A., Mesa Tudel A., Sole F., Sorigue M.,
RA   Zamora L., Granada I., Buschbeck M.;
RT   "Divergent leukaemia subclones as cellular models for testing
RT   vulnerabilities associated with gains in chromosomes 7, 8 or 18.";
RL   Sci. Rep. 11:21145-21145(2021).
//