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Cellosaurus U-343MG (CVCL_S471)

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Cell line name U-343MG
Synonyms U-343 MG; U-343-MG; U343MG; U-343; U343; 343 MG; 343MG; 343 MG(9)
Accession CVCL_S471
Resource Identification Initiative To cite this cell line use: U-343MG (RRID:CVCL_S471)
Comments Population: Caucasian.
Doubling time: 45 hours (PubMed=25984343).
Omics: Array-based CGH.
Omics: Deep exome analysis.
Omics: shRNA library screening.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Brain, temporal lobe; UBERON=UBERON_0001871.
HLA typing Source: PubMed=77569
Class I
HLA-AA*02,03
HLA-BB*07,27
Disease Glioblastoma (NCIt: C3058)
Glioblastoma (ORDO: Orphanet_360)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_4773 ! U-343MGa
Sex of cell Male
Age at sampling 54Y
Category Cancer cell line
STR profile Source(s): PubMed=22570425; PubMed=27582061

Markers:
AmelogeninX,Y
CSF1PO10,12
D2S133822,24
D3S135815,17
D5S81812,13
D7S8209,11
D8S117913,14
D13S3179,13
D16S5399,12
D18S5121,23 (PubMed=27582061)
23 (PubMed=22570425)
D19S43313,14
D21S1131,33.2
FGA19,20
Penta D9,10
Penta E10,12
TH016,9.3
TPOX8,9
vWA17 (PubMed=22570425)
17,18 (PubMed=27582061)

Run an STR similarity search on this cell line
Publications

PubMed=4134536; DOI=10.1002/ijc.2910120215
Westermark B.
The deficient density-dependent growth control of human malignant glioma cells and virus-transformed glia-like cells in culture.
Int. J. Cancer 12:438-451(1973)

PubMed=4359449; DOI=10.1111/j.1699-0463.1973.tb03573.x
Westermark B., Ponten J., Hugosson R.
Determinants for the establishment of permanent tissue culture lines from human gliomas.
Acta Pathol. Microbiol. Scand. A. 81:791-805(1973)

PubMed=4142792; DOI=10.1111/j.1601-5223.1974.tb01454.x
Mark J., Ponten J., Westermark B.
Cytogentical studies with G-band technique of established cell lines of human malignant glomas.
Hereditas 78:304-307(1974)

PubMed=4369403; DOI=10.1002/1097-0142(197408)34:2<274::AID-CNCR2820340209>3.0.CO;2-4
Wahlstrom T., Linder E., Saksela E., Westermark B.
Tumor-specific membrane antigens in established cell lines from gliomas.
Cancer 34:274-279(1974)

DOI=10.1007/978-1-4757-1647-4_7
Ponten J.
Neoplastic human glia cells in culture.
(In book chapter) Human tumor cells in vitro; Fogh J. (eds.); pp.175-206; Springer; New York; USA (1975)

PubMed=77569; DOI=10.1111/j.1399-0039.1978.tb01259.x
Espmark J.A., Ahlqvist-Roth L., Sarne L., Persson A.
Tissue typing of cells in culture. III. HLA antigens of established human cell lines. Attempts at typing by the mixed hemadsorption technique.
Tissue Antigens 11:279-286(1978)

PubMed=6260907; DOI=10.1097/00005072-198105000-00001
Bigner D.D., Bigner S.H., Ponten J., Westermark B., Mahaley M.S. Jr., Ruoslahti E., Herschman H., Eng L.F., Wikstrand C.J.
Heterogeneity of genotypic and phenotypic characteristics of fifteen permanent cell lines derived from human gliomas.
J. Neuropathol. Exp. Neurol. 40:201-229(1981)

PubMed=3518877; DOI=10.3109/07357908609038260
Fogh J.
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

PubMed=3675803
Bigner S.H., Bjerkvig R., Laerum O.D., Muhlbaier L.H., Bigner D.D.
DNA content and chromosomes in permanent cultured cell lines derived from malignant human gliomas.
Anal. Quant. Cytol. Histol. 9:435-444(1987)

PubMed=2454731
Nister M., Libermann T.A., Betsholtz C., Pettersson M., Claesson-Welsh L., Heldin C.-H., Schlessinger J., Westermark B.
Expression of messenger RNAs for platelet-derived growth factor and transforming growth factor-alpha and their receptors in human malignant glioma cell lines.
Cancer Res. 48:3910-3918(1988)

PubMed=1847665
Bongcam-Rudloff E., Nister M., Betsholtz C., Wang J.-L., Stenman G., Huebner K., Croce C.M., Westermark B.
Human glial fibrillary acidic protein: complementary DNA cloning, chromosome localization, and messenger RNA expression in human glioma cell lines of various phenotypes.
Cancer Res. 51:1553-1560(1991)

DOI=10.1016/B978-0-12-333530-2.50005-8
Nister M., Westermark B.
Human glioma cell lines.
(In book chapter) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.17-42; Academic Press; New York; USA (1994)

DOI=10.1007/0-306-46861-1_11
Ali-Osman F.
Brain tumors.
(In book chapter) Human cell culture. Vol. 2. Cancer cell lines part 2; Masters J.R.W., Palsson B.O. (eds.); pp.167-184; Kluwer Academic Publishers; New York; USA (1999)

PubMed=10402232; DOI=10.3892/ijo.15.2.237
Sharif T.R., Sharif M.
Overexpression of protein kinase C epsilon in astroglial brain tumor derived cell lines and primary tumor samples.
Int. J. Oncol. 15:237-243(1999)

PubMed=10416987; DOI=10.1111/j.1750-3639.1999.tb00536.x; PMCID=PMC8098486
Ishii N., Maier D., Merlo A., Tada M., Sawamura Y., Diserens A.-C., Van Meir E.G.
Frequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell lines.
Brain Pathol. 9:469-479(1999)

PubMed=11351043; DOI=10.1038/labinvest.3780280
Hui A.B.-Y., Lo K.-W., Yin X.-L., Poon W.-S., Ng H.-K.
Detection of multiple gene amplifications in glioblastoma multiforme using array-based comparative genomic hybridization.
Lab. Invest. 81:717-723(2001)

PubMed=21061448; DOI=10.1002/jat.1596
Pereira E.L.R., Lima P.D.L., Khayat A.S., Bahia M.O., Bezerra F.S., Andrade-Neto M., Montenegro R.C., Pessoa C., Costa-Lotufo L.V., Moraes M.O., Yoshioka F.K.N., Pinto G.R., Burbano R.R.
Inhibitory effect of pisosterol on human glioblastoma cell lines with C-MYC amplification.
J. Appl. Toxicol. 31:554-560(2011)

PubMed=21406405; DOI=10.1158/0008-5472.CAN-10-3112
Grzmil M., Morin P. Jr., Lino M.M., Merlo A., Frank S., Wang Y.-H., Moncayo G., Hemmings B.A.
MAP kinase-interacting kinase 1 regulates SMAD2-dependent TGF-beta signaling pathway in human glioblastoma.
Cancer Res. 71:2392-2402(2011)

PubMed=22570425; DOI=10.1093/neuonc/nos072; PMCID=PMC3367844
Bady P., Diserens A.-C., Castella V., Kalt S., Heinimann K., Hamou M.-F., Delorenzi M., Hegi M.E.
DNA fingerprinting of glioma cell lines and considerations on similarity measurements.
Neuro-oncol. 14:701-711(2012)

PubMed=25984343; DOI=10.1038/sdata.2014.35; PMCID=PMC4432652
Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S., East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H., Jiang G.-Z., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M., Harrington W., Gelfand E.T., Green T.M., Tomko M.J., Gopal S., Wong T.C., Li H.-B., Howell S., Stransky N., Liefeld T., Jang D., Bistline J., Meyers B.H., Armstrong S.A., Anderson K.C., Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P., Golub T.R., Root D.E., Hahn W.C.
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035-140035(2014)

PubMed=26496030; DOI=10.18632/oncotarget.6171; PMCID=PMC4791243
Patil V., Pal J., Somasundaram K.
Elucidating the cancer-specific genetic alteration spectrum of glioblastoma derived cell lines from whole exome and RNA sequencing.
Oncotarget 6:43452-43471(2015)

PubMed=27582061; DOI=10.1126/scitranslmed.aaf6853
Allen M., Bjerke M., Edlund H., Nelander S., Westermark B.
Origin of the U87MG glioma cell line: good news and bad news.
Sci. Transl. Med. 8:354re3.1-354re3.4(2016)

PubMed=33385022; DOI=10.1016/j.dib.2020.106643; PMCID=PMC7772531
de Sousa J.F., da Silva P., Serafim R.B., Nociti R.P., Moreira C.G., Silva W.A., Valente V.
RNA sequencing data of different grade astrocytoma cell lines.
Data Brief 34:106643.1-106643.13(2021)

Cross-references
Cell line databases/resources Cell_Model_Passport; SIDM01495
Anatomy/cell type resources BTO; BTO:0006221
Encyclopedic resources Wikidata; Q54973568
Experimental variables resources EFO; EFO_0022447
Polymorphism and mutation databases Cosmic; 849880
Cosmic; 2367503
Cosmic; 2491104
Cosmic; 2516043
Cosmic; 2701086
Entry history
Entry creation05-Nov-2013
Last entry update10-Sep-2024
Version number21