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Cellosaurus MCF-7 SimpleCell O-GalNAc (CVCL_S030)

[Text version]
Cell line name MCF-7 SimpleCell O-GalNAc
Synonyms MCF-7 SimpleCell; MCF-7 SC
Accession CVCL_S030
Resource Identification Initiative To cite this cell line use: MCF-7 SimpleCell O-GalNAc (RRID:CVCL_S030)
Comments Population: Caucasian.
Characteristics: Cell engineered to produce only truncated GalNAc or NeuAc-alpha-2-6-GalNAc O-glycans.
Knockout cell: Method=ZFN; HGNC; 24338; C1GALT1C1.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=23584533; DOI=10.1038/emboj.2013.79; PMCID=PMC3655468
Steentoft C., Vakhrushev S.Y., Joshi H.J., Kong Y., Vester-Christensen M.B., Schjoldager K.T.-B.G., Lavrsen K., Dabelsteen S., Pedersen N.B., Marcos-Silva L., Gupta R., Bennett E.P., Mandel U., Brunak S., Wandall H.H., Levery S.B., Clausen H.
Precision mapping of the human O-GalNAc glycoproteome through SimpleCell technology.
EMBO J. 32:1478-1488(2013)

Cross-references
Cell line databases/resources cancercelllines; CVCL_S030
Encyclopedic resources Wikidata; Q54904326
Entry history
Entry creation05-Nov-2013
Last entry update05-Oct-2023
Version number20