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Cellosaurus HCC4006rGEFI1muM (CVCL_RS47)

[Text version]
Cell line name HCC4006rGEFI1muM
Accession CVCL_RS47
Resource Identification Initiative To cite this cell line use: HCC4006rGEFI1muM (RRID:CVCL_RS47)
Comments Part of: Resistant Cancer Cell Line (RCCL) collection.
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:49668; Gefitinib (ZD1839; Iressa).
Omics: Deep exome analysis.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Mutation; HGNC; 3236; EGFR; Simple; p.Leu747_Glu749del (c.2239_2247delTAAGAGAA); ClinVar=VCV000177765; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Tyr205His (c.613T>C); ClinVar=VCV000376685; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1269 (HCC4006)
Sex of cell Male
Age at sampling >50Y
Category Cancer cell line
Web pages https://www.wass-michaelislab.org/rccl.php
Cell line databases/resources cancercelllines; CVCL_RS47
Encyclopedic resources Wikidata; Q54881730
Entry history
Entry creation05-Mar-2018
Last entry update05-Oct-2023
Version number9