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Cellosaurus DLD-1 PIK3CA E545K KO (CVCL_RQ05)

[Text version]
Cell line name DLD-1 PIK3CA E545K KO
Synonyms PIK3CA^(+/-) DLD-1
Accession CVCL_RQ05
Resource Identification Initiative To cite this cell line use: DLD-1 PIK3CA E545K KO (RRID:CVCL_RQ05)
Comments Population: Caucasian.
Characteristics: In DLD-1 one of the two PIK3CA alleles has a p.Glu545Lys mutation. This cell line is KO for the mutant allele (PubMed=15950905).
Knockout cell: Method=Recombinant Adeno-Associated Virus; HGNC; 8975; PIK3CA (Note=1 of 2 alleles, that with p.Glu545Lys).
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Cell type: Epithelial cell of colon; CL=CL_0011108.
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0248 (DLD-1)
Sex of cell Male
Age at sampling 67Y
Category Cancer cell line
Publications

PubMed=15950905; DOI=10.1016/j.ccr.2005.05.014
Samuels Y., Diaz L.A. Jr., Schmidt-Kittler O., Cummins J.M., DeLong L., Cheong I., Rago C., Huso D.L., Lengauer C., Kinzler K.W., Vogelstein B., Velculescu V.E.
Mutant PIK3CA promotes cell growth and invasion of human cancer cells.
Cancer Cell 7:561-573(2005)

Cross-references
Cell line collections (Providers) Horizon_Discovery; HD+105-001
Encyclopedic resources Wikidata; Q54831164
Entry history
Entry creation05-Mar-2018
Last entry update02-May-2024
Version number7