ID   DLD-1 PIK3CA E545K KO
AC   CVCL_RQ05
SY   PIK3CA^(+/-) DLD-1
DR   Horizon_Discovery; HD+105-001
DR   Wikidata; Q54831164
RX   PubMed=15950905;
CC   Population: Caucasian.
CC   Characteristics: In DLD-1 one of the two PIK3CA alleles has a p.Glu545Lys mutation. This cell line is KO for the mutant allele (PubMed=15950905).
CC   Knockout cell: Method=Recombinant Adeno-Associated Virus; HGNC; 8975; PIK3CA (Note=1 of 2 alleles, that with p.Glu545Lys).
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
CC   Cell type: Epithelial cell of colon; CL=CL_0011108.
DI   NCIt; C4349; Colon adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0248 ! DLD-1
SX   Male
AG   67Y
CA   Cancer cell line
DT   Created: 05-03-18; Last updated: 02-05-24; Version: 7
//
RX   PubMed=15950905; DOI=10.1016/j.ccr.2005.05.014;
RA   Samuels Y., Diaz L.A. Jr., Schmidt-Kittler O., Cummins J.M.,
RA   DeLong L., Cheong I., Rago C., Huso D.L., Lengauer C., Kinzler K.W.,
RA   Vogelstein B., Velculescu V.E.;
RT   "Mutant PIK3CA promotes cell growth and invasion of human cancer
RT   cells.";
RL   Cancer Cell 7:561-573(2005).
//