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Cellosaurus SU042-3 (CVCL_RK75)

[Text version]
Cell line name SU042-3
Accession CVCL_RK75
Resource Identification Initiative To cite this cell line use: SU042-3 (RRID:CVCL_RK75)
Comments Miscellaneous: Lacks the KRAS p.Gly13Asp mutations found in other clones.
Sequence variations
  • Mutation; HGNC; HGNC:795; ATM; Simple; p.Val2193Ile (c.6577G>A); ClinVar=VCV000231987; Zygosity=Unspecified; Note=Somatic (PubMed=28089908).
  • Mutation; HGNC; HGNC:2978; DNMT3A; Simple; p.Ser837Ter (c.2510C>G); Zygosity=Unspecified; Note=Somatic (PubMed=28089908).
  • Mutation; HGNC; HGNC:30045; SMG1; Simple; p.Leu250Val; Zygosity=Unspecified; Note=Somatic (PubMed=28089908).
  • Mutation; HGNC; HGNC:17575; SPEN; Simple; p.Thr1673Ser; Zygosity=Unspecified; Note=Somatic (PubMed=28089908).
Disease Adult acute myeloid leukemia (NCIt: C9154)
Acute myeloid leukemia (ORDO: Orphanet_519)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_RK73 ! SU042-1
CVCL_RK74 ! SU042-2
CVCL_RK76 ! SU042-4
CVCL_RK77 ! SU042-5
CVCL_RK78 ! SU42T-2
CVCL_RK79 ! SU42T-4
CVCL_RK80 ! SU42T-5
Sex of cell Female
Age at sampling 61Y
Category Induced pluripotent stem cell
Publications

PubMed=28089908; DOI=10.1016/j.stem.2016.11.018; PMCID=PMC5508733
Chao M.P., Gentles A.J., Chatterjee S., Lan F., Reinisch A., Corces M.R., Xavy S., Shen J.-F., Haag D., Chanda S., Sinha R., Morganti R.M., Nishimura T., Ameen M., Wu H.-D., Wernig M., Wu J.C., Majeti R.
Human AML-iPSCs reacquire leukemic properties after differentiation and model clonal variation of disease.
Cell Stem Cell 20:329-344.e7(2017)

Cross-references
Cell line databases/resources SKIP; SKIP001716
Encyclopedic resources Wikidata; Q54970752
Entry history
Entry creation05-Mar-2018
Last entry update19-Dec-2024
Version number8