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Cellosaurus Hepa/8F5 (CVCL_RI52)

[Text version]
Cell line name Hepa/8F5
Synonyms Hepa/8F(#5); Hepa8F5
Accession CVCL_RI52
Resource Identification Initiative To cite this cell line use: Hepa/8F5 (RRID:CVCL_RI52)
Comments Characteristics: When doxycycline-induced overexpresses 8 liver-enriched transcription factors (LETFs).
Genetic integration: Method=Transduction; Gene=MGI; MGI:99480; Cebpa.
Genetic integration: Method=Transduction; Gene=MGI; MGI:88373; Cebpb.
Genetic integration: Method=Transduction; Gene=MGI; MGI:104982; Cebpg.
Genetic integration: Method=Transduction; Gene=MGI; MGI:1347476; Foxa2.
Genetic integration: Method=Transduction; Gene=MGI; MGI:98504; Hnf1a.
Genetic integration: Method=Transduction; Gene=MGI; MGI:98505; Hnf1b.
Genetic integration: Method=Transduction; Gene=MGI; MGI:109128; Hnf4a.
Genetic integration: Method=Transduction; Gene=MGI; MGI:1196423; Onecut1.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Disease Hepatocellular carcinoma of the mouse (NCIt: C38756)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C57L.
Hierarchy Parent: CVCL_0327 (Hepa 1-6)
Children:
CVCL_B5ZG (Hepa/HS)
Sex of cell Female
Category Cancer cell line
Publications

DOI=10.1016/j.bej.2011.10.004
Yamamoto H., Kawabe Y., Ito A., Kamihira M.
Enhanced liver functions in mouse hepatoma cells by induced overexpression of liver-enriched transcription factors.
Biochem. Eng. J. 60:67-73(2012)

PubMed=28847578; DOI=10.1016/j.jbiosc.2017.07.011
Yamamoto H., Tonello J.M., Sambuichi T., Kawabe Y., Ito A., Kamihira M.
Characterization of genetically engineered mouse hepatoma cells with inducible liver functions by overexpression of liver-enriched transcription factors.
J. Biosci. Bioeng. 125:131-139(2018)

PubMed=34149171; DOI=10.1007/s10616-021-00457-4; PMCID=PMC8166997
Kitano H., Nagae Y., Kawabe Y., Ito A., Kamihira M.
Development of a genetically modified hepatoma cell line with heat-inducible high liver function.
Cytotechnology 73:353-362(2021)

Cross-references
Cell line collections (Providers) RCB; RCB4661
Encyclopedic resources Wikidata; Q54882819
Gene expression databases ArrayExpress; E-MTAB-5770
Entry history
Entry creation05-Mar-2018
Last entry update10-Sep-2024
Version number9