Cellosaurus Hepa/HS (CVCL_B5ZG)
| Cell line name | Hepa/HS |
|---|---|
| Accession | CVCL_B5ZG |
| Resource Identification Initiative | To cite this cell line use: Hepa/HS (RRID:CVCL_B5ZG) |
| Comments | Characteristics: When doxycycline-induced overexpresses 8 liver-enriched transcription factors (LETFs) (from parent cell line). Characteristics: The parent cell line was modified to enable switching between proliferation and expression of proteins for liver function in response to heat by introducing a new heat-inducible gene expression/amplification system (pHSP-tTA-TRE-tTA-pEF1a-Puro) which was transferred using a PiggyBac transposon vector (PubMed=34149171). Genetic integration: Method=PiggyBac transposition; Gene=UniProtKB; P13249; S.alboniger pac (PuroR). Genetic integration: Method=Transduction; Gene=MGI; MGI:99480; Cebpa. Genetic integration: Method=Transduction; Gene=MGI; MGI:88373; Cebpb. Genetic integration: Method=Transduction; Gene=MGI; MGI:104982; Cebpg. Genetic integration: Method=Transduction; Gene=MGI; MGI:1347476; Foxa2. Genetic integration: Method=Transduction; Gene=MGI; MGI:98504; Hnf1a. Genetic integration: Method=Transduction; Gene=MGI; MGI:98505; Hnf1b. Genetic integration: Method=Transduction; Gene=MGI; MGI:109128; Hnf4a. Genetic integration: Method=Transduction; Gene=MGI; MGI:1196423; Onecut1. Omics: Transcriptome analysis by microarray. Derived from site: In situ; Liver; UBERON=UBERON_0002107. |
| Disease | Hepatocellular carcinoma of the mouse (NCIt: C38756) |
| Species of origin | Mus musculus (Mouse) (NCBI Taxonomy: 10090) |
| Hierarchy | Parent: CVCL_RI52 (Hepa/8F5) |
| Sex of cell | Female |
| Category | Cancer cell line |
| Publications | PubMed=34149171; DOI=10.1007/s10616-021-00457-4; PMCID=PMC8166997 |
| Cross-references | |
| Encyclopedic resources | Wikidata; Q111733353 |
| Entry history | |
| Entry creation | 17-Mar-2022 |
| Last entry update | 10-Sep-2024 |
| Version number | 5 |