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Cellosaurus Nalm6-Fluc-hNIS (CVCL_RA35)

[Text version]
Cell line name Nalm6-Fluc-hNIS
Accession CVCL_RA35
Resource Identification Initiative To cite this cell line use: Nalm6-Fluc-hNIS (RRID:CVCL_RA35)
Comments Population: Caucasian.
Characteristics: Reporter cell line, transduced with the LV-Luc2-P2A-hNIS vector encoding for luciferase linked via a P2A cleavage peptide to the human SLC5A5 gene and under control of the spleen focus-forming virus (SFFV) promoter (Imanis=CL143).
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11040; SLC5A5.
Genetic integration: Method=Transduction; Gene=UniProtKB; P08659; Firefly luciferase.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene fusion; HGNC; HGNC:50800; DUX4 + HGNC; HGNC:5477; IGH; Name(s)=IGH-DUX4; Note=The translocation occurs in the silenced IGH allele (from parent cell line).
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Arg1068Ter (c.3202C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Ala146Thr (c.436G>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9864; RARA; Simple; p.Gln45Ter (c.133C>T); ClinVar=VCV000393019; Zygosity=Heterozygous (from parent cell line).
Disease Adult B acute lymphoblastic leukemia (NCIt: C9143)
Precursor B-cell acute lymphoblastic leukemia (ORDO: Orphanet_99860)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0092 (NALM-6)
Sex of cell Male
Age at sampling 19Y
Category Cancer cell line
Publications

PubMed=30674994; DOI=10.1038/s41417-019-0081-2; PMCID=PMC7170803
Vandergaast R., Khongwichit S., Jiang H.-L., DeGrado T.R., Peng K.-W., Smith D.R., Russell S.J., Suksanpaisan L.
Enhanced noninvasive imaging of oncology models using the NIS reporter gene and bioluminescence imaging.
Cancer Gene Ther. 27:179-188(2020)

Cross-references
Cell line collections (Providers) Imanis; CL143
Cell line databases/resources cancercelllines; CVCL_RA35
Encyclopedic resources Wikidata; Q54907444
Entry history
Entry creation05-Mar-2018
Last entry update19-Dec-2024
Version number14