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Cellosaurus HaCaT YAP-5SA (CVCL_QX10)

[Text version]
Cell line name HaCaT YAP-5SA
Synonyms YAP_5SA_HaCAT
Accession CVCL_QX10
Resource Identification Initiative To cite this cell line use: HaCaT YAP-5SA (RRID:CVCL_QX10)
Comments Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:16262; YAP1 (Note=With p.Ser61Ala, p.Ser109Ala, p.Ser127Ala, p.Ser164Ala and p.Ser381Ala = YAP-5SA).
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Back, skin, epidermis; UBERON=UBERON_0001068+UBERON_0001003.
Cell type: Keratinocyte; CL=CL_0000312.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.His179Tyr (c.535C>T); ClinVar=VCV000127815; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg282Trp (c.843_844CC>TT); Zygosity=Heterozygous (from parent cell line).
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0038 (HaCaT)
Sex of cell Male
Age at sampling 62Y
Category Spontaneously immortalized cell line
Publications

PubMed=26989177; DOI=10.1242/dev.133728; PMCID=PMC4874484
Elbediwy A., Vincent-Mistiaen Z.I., Spencer-Dene B., Stone R.K., Boeing S., Wculek S.K., Cordero J., Tan E.H., Ridgway R., Brunton V.G., Sahai E., Gerhardt H., Behrens A., Malanchi I., Sansom O.J., Thompson B.J.
Integrin signalling regulates YAP and TAZ to control skin homeostasis.
Development 143:1674-1687(2016)

Cross-references
Encyclopedic resources Wikidata; Q54872315
Gene expression databases GEO; GSM2112564
GEO; GSM2112565
GEO; GSM2112566
Entry history
Entry creation15-Nov-2017
Last entry update19-Dec-2024
Version number13