Cellosaurus cell line MDA-T120 (CVCL

Cellosaurus MDA-T120 (CVCL_QW85)

[Text version]

Cell line name

MDA-T120

Accession

CVCL_QW85

Resource Identification Initiative

To cite this cell line use: MDA-T120 (RRID:CVCL_QW85)

Comments

Doubling time: ~48-72 hours (ATCC=CRL-3355).
Omics: Transcriptome analysis by microarray.
Derived from site: Metastatic; Cervical lymph node; UBERON=UBERON_0002429.

Sequence variations

Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (PubMed=25427145; PubMed=30737244).
Mutation; HGNC; HGNC:7773; NF2; Simple; p.Glu182Ter (c.544G>T); ClinVar=VCV000003289; Zygosity=Homozygous (PubMed=30737244).
Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Heterozygous; Note=In promoter (PubMed=25427145; PubMed=30737244).
Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg280Thr (c.839G>C); ClinVar=VCV000012368; Zygosity=Homozygous (PubMed=25427145; PubMed=30737244).

Disease

Thyroid gland papillary carcinoma (NCIt: C4035)
Differentiated thyroid carcinoma (ORDO: Orphanet_146)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Female

Age at sampling

72Y

Category

Cancer cell line

STR profile

Source(s): ATCC=CRL-3355; PubMed=25427145; PubMed=30737244

Markers:

Amelogenin	X
CSF1PO	12,14
D5S818	11,12
D7S820	10,11
D13S317	11
D16S539	13
TH01	6,9
TPOX	8,9
vWA	14,17

Publications

PubMed=25427145; DOI=10.1210/jc.2014-2624; PMCID=PMC4318904
Henderson Y.C., Ahn S.-H., Ryu J., Chen Y.-Y., Williams M.D., El-Naggar A.K., Gagea M., Schweppe R.E., Haugen B.R., Lai S.Y., Clayman G.L.
Development and characterization of six new human papillary thyroid carcinoma cell lines.
J. Clin. Endocrinol. Metab. 100:E243-E252(2015)

PubMed=30737244; DOI=10.1158/1078-0432.CCR-18-2953; PMCID=PMC6522280
Landa I., Pozdeyev N., Korch C.T., Marlow L.A., Smallridge R.C., Copland J.A. 3rd, Henderson Y.C., Lai S.Y., Clayman G.L., Onoda N., Tan A.-C., Garcia-Rendueles M.E.R., Knauf J.A., Haugen B.R., Fagin J.A., Schweppe R.E.
Comprehensive genetic characterization of human thyroid cancer cell lines: a validated panel for preclinical studies.
Clin. Cancer Res. 25:3141-3151(2019)

Cross-references

Cell line collections (Providers)

ATCC; CRL-3355

Cell line databases/resources

cancercelllines; CVCL_QW85

Encyclopedic resources

Wikidata; Q54904658

Polymorphism and mutation databases

Cosmic; 2612757

Entry history

Entry creation

15-Nov-2017

Last entry update

19-Dec-2024

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