ID   MDA-T120
AC   CVCL_QW85
DR   ATCC; CRL-3355
DR   cancercelllines; CVCL_QW85
DR   Cosmic; 2612757
DR   Wikidata; Q54904658
RX   PubMed=25427145;
RX   PubMed=30737244;
CC   Doubling time: ~48-72 hours (ATCC=CRL-3355).
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (PubMed=25427145; PubMed=30737244).
CC   Sequence variation: Mutation; HGNC; HGNC:7773; NF2; Simple; p.Glu182Ter (c.544G>T); ClinVar=VCV000003289; Zygosity=Homozygous (PubMed=30737244).
CC   Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Heterozygous; Note=In promoter (PubMed=25427145; PubMed=30737244).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg280Thr (c.839G>C); ClinVar=VCV000012368; Zygosity=Homozygous (PubMed=25427145; PubMed=30737244).
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: Metastatic; Cervical lymph node; UBERON=UBERON_0002429.
ST   Source(s): ATCC=CRL-3355; PubMed=25427145; PubMed=30737244
ST   Amelogenin: X
ST   CSF1PO: 12,14
ST   D13S317: 11
ST   D16S539: 13
ST   D5S818: 11,12
ST   D7S820: 10,11
ST   TH01: 6,9
ST   TPOX: 8,9
ST   vWA: 14,17
DI   NCIt; C4035; Thyroid gland papillary carcinoma
DI   ORDO; Orphanet_146; Differentiated thyroid carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   72Y
CA   Cancer cell line
DT   Created: 15-11-17; Last updated: 19-12-24; Version: 16
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RX   PubMed=25427145; DOI=10.1210/jc.2014-2624; PMCID=PMC4318904;
RA   Henderson Y.C., Ahn S.-H., Ryu J., Chen Y.-Y., Williams M.D.,
RA   El-Naggar A.K., Gagea M., Schweppe R.E., Haugen B.R., Lai S.Y.,
RA   Clayman G.L.;
RT   "Development and characterization of six new human papillary thyroid
RT   carcinoma cell lines.";
RL   J. Clin. Endocrinol. Metab. 100:E243-E252(2015).
//
RX   PubMed=30737244; DOI=10.1158/1078-0432.CCR-18-2953; PMCID=PMC6522280;
RA   Landa I., Pozdeyev N., Korch C.T., Marlow L.A., Smallridge R.C.,
RA   Copland J.A. 3rd, Henderson Y.C., Lai S.Y., Clayman G.L., Onoda N.,
RA   Tan A.-C., Garcia-Rendueles M.E.R., Knauf J.A., Haugen B.R.,
RA   Fagin J.A., Schweppe R.E.;
RT   "Comprehensive genetic characterization of human thyroid cancer cell
RT   lines: a validated panel for preclinical studies.";
RL   Clin. Cancer Res. 25:3141-3151(2019).
//