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Cellosaurus T243 (CVCL_M976)

[Text version]
Cell line name T243
Accession CVCL_M976
Resource Identification Initiative To cite this cell line use: T243 (RRID:CVCL_M976)
Comments Omics: Transcriptomics; Microarray.
Derived from site: In situ; Thyroid gland; UBERON=UBERON_0002046.
Sequence variations
  • Mutation; HGNC; HGNC:2681; DAXX; Simple; p.Arg318Ter (c.952C>T); Zygosity=Homozygous (PubMed=30737244).
  • Mutation; HGNC; HGNC:3373; EP300; Simple; p.Pro723fs (c.2167delC); Zygosity=Heterozygous (PubMed=30737244).
  • Mutation; HGNC; HGNC:11957; MED12; Simple; p.Arg282Ter (c.844C>T); Zygosity=Homozygous (PubMed=30737244).
  • Mutation; HGNC; HGNC:7325; MSH2; Simple; p.Gln130Valfs*2 (c.388_389delCA); ClinVar=VCV000091090; Zygosity=Homozygous (PubMed=30737244).
  • Mutation; HGNC; HGNC:11355; STAG2; Simple; p.Arg604Ter (c.1810C>T); Zygosity=Homozygous (PubMed=30737244).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr103Thrfs*20 (c.306delC) (p.Thr102fs); Zygosity=Homozygous (PubMed=30737244).
Disease Poorly differentiated thyroid gland carcinoma (NCIt: C6040)
Thyroid carcinoma (ORDO: Orphanet_100088)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 67Y
Category Cancer cell line
STR profile Source(s): PubMed=30737244

Markers:
AmelogeninX
CSF1PO9,10,12
D3S135814,15
D5S81811,13
D7S8209,12
D8S117912,13
D13S31711,12
D16S53913
D18S5115,16,17
D21S1132.2
FGA19
TH018
TPOX11
vWA16,18

Run an STR similarity search on this cell line
Publications

PubMed=17406368; DOI=10.1038/sj.bjc.6603578; PMCID=PMC2360140
Rodrigues R.F., Roque L., Krug T., Leite V.
Poorly differentiated and anaplastic thyroid carcinomas: chromosomal and oligo-array profile of five new cell lines.
Br. J. Cancer 96:1237-1245(2007)

PubMed=30737244; DOI=10.1158/1078-0432.CCR-18-2953; PMCID=PMC6522280
Landa I., Pozdeyev N., Korch C.T., Marlow L.A., Smallridge R.C., Copland J.A. 3rd, Henderson Y.C., Lai S.Y., Clayman G.L., Onoda N., Tan A.-C., Garcia-Rendueles M.E.R., Knauf J.A., Haugen B.R., Fagin J.A., Schweppe R.E.
Comprehensive genetic characterization of human thyroid cancer cell lines: a validated panel for preclinical studies.
Clin. Cancer Res. 25:3141-3151(2019)

Cross-references
Cell line databases/resources cancercelllines; CVCL_M976
Encyclopedic resources Wikidata; Q54971461
Polymorphism and mutation databases Cosmic; 2186785
Entry history
Entry creation05-Nov-2013
Last entry update10-Apr-2025
Version number16