Cell line name |
T243 |
Accession |
CVCL_M976 |
Resource Identification Initiative |
To cite this cell line use: T243 (RRID:CVCL_M976) |
Comments |
Omics: Transcriptome analysis by microarray. Derived from site: In situ; Thyroid gland; UBERON=UBERON_0002046. |
Sequence variations |
- Mutation; HGNC; HGNC:2681; DAXX; Simple; p.Arg318Ter (c.952C>T); Zygosity=Homozygous (PubMed=30737244).
- Mutation; HGNC; HGNC:3373; EP300; Simple; p.Pro723fs (c.2167delC); Zygosity=Heterozygous (PubMed=30737244).
- Mutation; HGNC; HGNC:11957; MED12; Simple; p.Arg282Ter (c.844C>T); Zygosity=Homozygous (PubMed=30737244).
- Mutation; HGNC; HGNC:7325; MSH2; Simple; p.Gln130Valfs*2 (c.388_389delCA); ClinVar=VCV000091090; Zygosity=Homozygous (PubMed=30737244).
- Mutation; HGNC; HGNC:11355; STAG2; Simple; p.Arg604Ter (c.1810C>T); Zygosity=Homozygous (PubMed=30737244).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr103Thrfs*20 (c.306delC) (p.Thr102fs); Zygosity=Homozygous (PubMed=30737244).
|
Disease |
Poorly differentiated thyroid gland carcinoma (NCIt: C6040) Thyroid carcinoma (ORDO: Orphanet_100088) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Sex of cell |
Male |
Age at sampling |
67Y |
Category |
Cancer cell line |
STR profile |
Source(s): PubMed=30737244
Markers:Amelogenin | X |
CSF1PO | 9,10,12 |
D3S1358 | 14,15 |
D5S818 | 11,13 |
D7S820 | 9,12 |
D8S1179 | 12,13 |
D13S317 | 11,12 |
D16S539 | 13 |
D18S51 | 15,16,17 |
D21S11 | 32.2 |
FGA | 19 |
TH01 | 8 |
TPOX | 11 |
vWA | 16,18 |
Run an STR similarity search on this cell line |
Publications | PubMed=17406368; DOI=10.1038/sj.bjc.6603578; PMCID=PMC2360140 Rodrigues R.F., Roque L., Krug T., Leite V. Poorly differentiated and anaplastic thyroid carcinomas: chromosomal and oligo-array profile of five new cell lines. Br. J. Cancer 96:1237-1245(2007) PubMed=30737244; DOI=10.1158/1078-0432.CCR-18-2953; PMCID=PMC6522280 Landa I., Pozdeyev N., Korch C.T., Marlow L.A., Smallridge R.C., Copland J.A. 3rd, Henderson Y.C., Lai S.Y., Clayman G.L., Onoda N., Tan A.-C., Garcia-Rendueles M.E.R., Knauf J.A., Haugen B.R., Fagin J.A., Schweppe R.E. Comprehensive genetic characterization of human thyroid cancer cell lines: a validated panel for preclinical studies. Clin. Cancer Res. 25:3141-3151(2019) |
Cross-references |
Cell line databases/resources |
cancercelllines; CVCL_M976
|
Encyclopedic resources |
Wikidata; Q54971461
|
Polymorphism and mutation databases |
Cosmic; 2186785
|
Entry history |
Entry creation | 05-Nov-2013 |
Last entry update | 19-Dec-2024 |
Version number | 15 |
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