ID   T243
AC   CVCL_M976
DR   cancercelllines; CVCL_M976
DR   Cosmic; 2186785
DR   Wikidata; Q54971461
RX   PubMed=17406368;
RX   PubMed=30737244;
CC   Sequence variation: Mutation; HGNC; HGNC:2681; DAXX; Simple; p.Arg318Ter (c.952C>T); Zygosity=Homozygous (PubMed=30737244).
CC   Sequence variation: Mutation; HGNC; HGNC:3373; EP300; Simple; p.Pro723fs (c.2167delC); Zygosity=Heterozygous (PubMed=30737244).
CC   Sequence variation: Mutation; HGNC; HGNC:11957; MED12; Simple; p.Arg282Ter (c.844C>T); Zygosity=Homozygous (PubMed=30737244).
CC   Sequence variation: Mutation; HGNC; HGNC:7325; MSH2; Simple; p.Gln130Valfs*2 (c.388_389delCA); ClinVar=VCV000091090; Zygosity=Homozygous (PubMed=30737244).
CC   Sequence variation: Mutation; HGNC; HGNC:11355; STAG2; Simple; p.Arg604Ter (c.1810C>T); Zygosity=Homozygous (PubMed=30737244).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr103Thrfs*20 (c.306delC) (p.Thr102fs); Zygosity=Homozygous (PubMed=30737244).
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: In situ; Thyroid gland; UBERON=UBERON_0002046.
ST   Source(s): PubMed=30737244
ST   Amelogenin: X
ST   CSF1PO: 9,10,12
ST   D13S317: 11,12
ST   D16S539: 13
ST   D18S51: 15,16,17
ST   D21S11: 32.2
ST   D3S1358: 14,15
ST   D5S818: 11,13
ST   D7S820: 9,12
ST   D8S1179: 12,13
ST   FGA: 19
ST   TH01: 8
ST   TPOX: 11
ST   vWA: 16,18
DI   NCIt; C6040; Poorly differentiated thyroid gland carcinoma
DI   ORDO; Orphanet_100088; Thyroid carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   67Y
CA   Cancer cell line
DT   Created: 05-11-13; Last updated: 19-12-24; Version: 15
//
RX   PubMed=17406368; DOI=10.1038/sj.bjc.6603578; PMCID=PMC2360140;
RA   Rodrigues R.F., Roque L., Krug T., Leite V.;
RT   "Poorly differentiated and anaplastic thyroid carcinomas: chromosomal
RT   and oligo-array profile of five new cell lines.";
RL   Br. J. Cancer 96:1237-1245(2007).
//
RX   PubMed=30737244; DOI=10.1158/1078-0432.CCR-18-2953; PMCID=PMC6522280;
RA   Landa I., Pozdeyev N., Korch C.T., Marlow L.A., Smallridge R.C.,
RA   Copland J.A. 3rd, Henderson Y.C., Lai S.Y., Clayman G.L., Onoda N.,
RA   Tan A.-C., Garcia-Rendueles M.E.R., Knauf J.A., Haugen B.R.,
RA   Fagin J.A., Schweppe R.E.;
RT   "Comprehensive genetic characterization of human thyroid cancer cell
RT   lines: a validated panel for preclinical studies.";
RL   Clin. Cancer Res. 25:3141-3151(2019).
//