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Cellosaurus SK-Hep-1/CDDP (CVCL_M182)

[Text version]
Cell line name SK-Hep-1/CDDP
Synonyms SK-Hep1/DDP
Accession CVCL_M182
Resource Identification Initiative To cite this cell line use: SK-Hep-1/CDDP (RRID:CVCL_M182)
Comments Problematic cell line: Misclassified. Parent cell line (SK-HEP-1) was originally described as originating from an adenocarcinoma of liver and thus classified as hepatocellular carcinoma. Later studies show that it most probably has arisen from endothelial cells.
Population: Caucasian.
Karyotypic information: Has lost chromosome Y (from parent cell line).
Selected for resistance to: ChEBI; CHEBI:27899; Cisplatin (CDDP).
Caution: PubMed=20458768 describes SK-Hep-1/CDDP and does not cite PubMed=20109345 which describes SK-Hep1/DDP. As the two papers are from the same authors and that the described cell lines have identical characteristics it is probable that they are identical.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Cell type: Endothelial cell; CL=CL_0000115.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
Disease Liver and intrahepatic bile duct epithelial neoplasm (NCIt: C7106)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0525 (SK-HEP-1)
Sex of cell Male
Age at sampling 52Y
Category Cancer cell line

Zhou Y., Ling X.-L.
Establishment of a cisplatin-induced multidrug resistance cell line SK-Hep1/DDP.
Chin. J. Cancer 29:167-171(2010)

PubMed=20458768; DOI=10.3748/wjg.v16.i18.2291
Zhou Y., Ling X.-L., Li S.-W., Li X.-Q., Yan B.
Establishment of a human hepatoma multidrug resistant cell line in vitro.
World J. Gastroenterol. 16:2291-2297(2010)

Cell line databases/resources cancercelllines; CVCL_M182
Encyclopedic resources Wikidata; Q54953671
Entry history
Entry creation06-May-2013
Last entry update05-Oct-2023
Version number18