ID   SK-Hep-1/CDDP
AC   CVCL_M182
SY   SK-Hep1/DDP
DR   cancercelllines; CVCL_M182
DR   Wikidata; Q54953671
RX   PubMed=20109345;
RX   PubMed=20458768;
CC   Problematic cell line: Misclassified. Parent cell line (SK-HEP-1) was originally described as originating from an adenocarcinoma of liver and thus classified as hepatocellular carcinoma. Later studies show that it most probably has arisen from endothelial cells.
CC   Population: Caucasian.
CC   Karyotypic information: Has lost chromosome Y (from parent cell line).
CC   Selected for resistance to: ChEBI; CHEBI:27899; Cisplatin (CDDP).
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
CC   Caution: PubMed=20458768 describes SK-Hep-1/CDDP and does not cite PubMed=20109345 which describes SK-Hep1/DDP. As the two papers are from the same authors and that the described cell lines have identical characteristics it is probable that they are identical.
CC   Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
CC   Cell type: Endothelial cell; CL=CL_0000115.
DI   NCIt; C7106; Liver and intrahepatic bile duct epithelial neoplasm
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0525 ! SK-HEP-1
SX   Male
AG   52Y
CA   Cancer cell line
DT   Created: 06-05-13; Last updated: 05-10-23; Version: 18
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RX   PubMed=20109345;
RA   Zhou Y., Ling X.-L.;
RT   "Establishment of a cisplatin-induced multidrug resistance cell line
RT   SK-Hep1/DDP.";
RL   Chin. J. Cancer 29:167-171(2010).
//
RX   PubMed=20458768; DOI=10.3748/wjg.v16.i18.2291;
RA   Zhou Y., Ling X.-L., Li S.-W., Li X.-Q., Yan B.;
RT   "Establishment of a human hepatoma multidrug resistant cell line in
RT   vitro.";
RL   World J. Gastroenterol. 16:2291-2297(2010).
//