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Cellosaurus COG-LL-332h (CVCL_M163)

[Text version]
Cell line name COG-LL-332h
Accession CVCL_M163
Resource Identification Initiative To cite this cell line use: COG-LL-332h (RRID:CVCL_M163)
Comments Characteristics: Hypoxic cell line grown at 5% O2.
Doubling time: 30-34 hours (COG).
Omics: Deep quantitative proteome analysis.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Cell type: T-cell; CL=CL_0000084.
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_B3TI ! COG-LL-329
CVCL_M162 ! COG-LL-329h
CVCL_B3TJ ! COG-LL-332
Sex of cell Male
Age at sampling 10Y
Category Cancer cell line
STR profile Source(s): COG

Markers:
AmelogeninX,Y
CSF1PO10,12
D2S133817,19
D3S135815,16
D5S81810,13
D7S8208,12
D8S117910,13
D13S31712
D16S53912
D18S5117,18
D19S43313.2,15
D21S1129,31.2
FGA24,25
TH016,8
TPOX8,10
vWA15,16

Run an STR similarity search on this cell line
Web pages https://www.cccells.org/cellreqs-leuk.php
https://www.cccells.org/PDF_Files/LL-PDX/COG-LL-332.pdf
Publications

PubMed=22137317; DOI=10.1016/j.leukres.2011.10.022; PMCID=PMC3264762
Zhang C., Ryu Y.-K., Chen T.Z., Hall C.P., Webster D.R., Kang M.H.
Synergistic activity of rapamycin and dexamethasone in vitro and in vivo in acute lymphoblastic leukemia via cell-cycle arrest and apoptosis.
Leuk. Res. 36:342-349(2012)

PubMed=26080839; DOI=10.1158/1078-0432.CCR-15-0114; PMCID=PMC4681691
Hall C.P., Reynolds C.P., Kang M.H.
Modulation of glucocorticoid resistance in pediatric T-cell acute lymphoblastic leukemia by increasing BIM expression with the PI3K/mTOR inhibitor BEZ235.
Clin. Cancer Res. 22:621-632(2016)

PubMed=28119491; DOI=10.1158/1535-7163.MCT-16-0749
Makena M.R., Koneru B., Nguyen T.H., Kang M.H., Reynolds C.P.
Reactive oxygen species-mediated synergism of fenretinide and romidepsin in preclinical models of T-cell lymphoid malignancies.
Mol. Cancer Ther. 16:649-661(2017)

PubMed=35354797; DOI=10.1038/s41467-022-29224-5; PMCID=PMC8967900
Leo I.R., Aswad L., Stahl M., Kunold E., Post F., Erkers T., Struyf N., Mermelekas G., Joshi R.N., Gracia-Villacampa E., Ostling P., Kallioniemi O.-P., Pokrovskaja Tamm K., Siavelis I., Lehtio J., Vesterlund M., Jafari R.
Integrative multi-omics and drug response profiling of childhood acute lymphoblastic leukemia cell lines.
Nat. Commun. 13:1691.1-1691.19(2022)

Cross-references
Encyclopedic resources Wikidata; Q54813973
Gene expression databases GEO; GSM5137712
Proteomic databases PRIDE; PXD023662
Entry history
Entry creation06-May-2013
Last entry update02-May-2024
Version number14