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Cellosaurus COG-LL-317 (CVCL_M159)

[Text version]
Cell line name COG-LL-317
Accession CVCL_M159
Resource Identification Initiative To cite this cell line use: COG-LL-317 (RRID:CVCL_M159)
Comments Part of: NCI Pediatric Preclinical Testing Program (PPTP) cell line panel.
Doubling time: 21 hours (PubMed=20922763); 30-40 hours (COG).
Karyotypic information: 46,XY,t(8;14)(q24.1;q11.2) (COG).
Omics: Deep quantitative proteome analysis.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Cell type: T-cell; CL=CL_0000084.
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_M160 ! COG-LL-317h
Sex of cell Male
Age at sampling 1Y7M
Category Cancer cell line
STR profile Source(s): COG; PubMed=20922763

Markers:
AmelogeninX,Y
CSF1PO10
D2S133817,18
D3S135816,17
D5S81811,13
D7S82011,13
D8S117915
D13S3178,12
D16S5399,11
D18S5114,18
D19S43314,16
D21S1130
FGA20,23
TH017,8
TPOX8,11
vWA16,17

Run an STR similarity search on this cell line
Web pages https://www.cccells.org/PDF_Files/LL-PDX/COG-LL-317.pdf
https://www.cccells.org/suppdata/dl/3karyotypes_2007-02-09.pdf
http://www.pptpinvitro.org/cell_lines_panel.php
Publications

PubMed=19298590; DOI=10.1111/j.1365-2141.2009.07631.x
Kang M.H., Harutyunyan N., Hall C.P., Papa R.A., Lock R.B.
Methotrexate and aminopterin exhibit similar in vitro and in vivo preclinical activity against acute lymphoblastic leukaemia and lymphoma.
Br. J. Haematol. 145:389-393(2009)

PubMed=20922763; DOI=10.1002/pbc.22801; PMCID=PMC3005554
Kang M.H., Smith M.A., Morton C.L., Keshelava N., Houghton P.J., Reynolds C.P.
National Cancer Institute pediatric preclinical testing program: model description for in vitro cytotoxicity testing.
Pediatr. Blood Cancer 56:239-249(2011)

PubMed=35354797; DOI=10.1038/s41467-022-29224-5; PMCID=PMC8967900
Leo I.R., Aswad L., Stahl M., Kunold E., Post F., Erkers T., Struyf N., Mermelekas G., Joshi R.N., Gracia-Villacampa E., Ostling P., Kallioniemi O.-P., Pokrovskaja Tamm K., Siavelis I., Lehtio J., Vesterlund M., Jafari R.
Integrative multi-omics and drug response profiling of childhood acute lymphoblastic leukemia cell lines.
Nat. Commun. 13:1691.1-1691.19(2022)

Cross-references
Encyclopedic resources Wikidata; Q54813969
Gene expression databases GEO; GSM5137710
Proteomic databases PRIDE; PXD023662
Entry history
Entry creation06-May-2013
Last entry update05-Oct-2023
Version number16