ID   COG-LL-317
AC   CVCL_M159
DR   GEO; GSM5137710
DR   PRIDE; PXD023662
DR   Wikidata; Q54813969
RX   PubMed=19298590;
RX   PubMed=20922763;
RX   PubMed=35354797;
WW   https://www.cccells.org/PDF_Files/LL-PDX/COG-LL-317.pdf
WW   https://www.cccells.org/suppdata/dl/3karyotypes_2007-02-09.pdf
WW   http://www.pptpinvitro.org/cell_lines_panel.php
CC   Part of: NCI Pediatric Preclinical Testing Program (PPTP) cell line panel.
CC   Doubling time: 21 hours (PubMed=20922763); 30-40 hours (COG).
CC   Karyotypic information: 46,XY,t(8;14)(q24.1;q11.2) (COG).
CC   Omics: Deep quantitative proteome analysis.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
CC   Cell type: T-cell; CL=CL_0000084.
ST   Source(s): COG; PubMed=20922763
ST   Amelogenin: X,Y
ST   CSF1PO: 10
ST   D13S317: 8,12
ST   D16S539: 9,11
ST   D18S51: 14,18
ST   D19S433: 14,16
ST   D21S11: 30
ST   D2S1338: 17,18
ST   D3S1358: 16,17
ST   D5S818: 11,13
ST   D7S820: 11,13
ST   D8S1179: 15
ST   FGA: 20,23
ST   TH01: 7,8
ST   TPOX: 8,11
ST   vWA: 16,17
DI   NCIt; C7953; Childhood T acute lymphoblastic leukemia
DI   ORDO; Orphanet_99861; Precursor T-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_M160 ! COG-LL-317h
SX   Male
AG   1Y7M
CA   Cancer cell line
DT   Created: 06-05-13; Last updated: 05-10-23; Version: 16
//
RX   PubMed=19298590; DOI=10.1111/j.1365-2141.2009.07631.x;
RA   Kang M.H., Harutyunyan N., Hall C.P., Papa R.A., Lock R.B.;
RT   "Methotrexate and aminopterin exhibit similar in vitro and in vivo
RT   preclinical activity against acute lymphoblastic leukaemia and
RT   lymphoma.";
RL   Br. J. Haematol. 145:389-393(2009).
//
RX   PubMed=20922763; DOI=10.1002/pbc.22801;
RA   Kang M.H., Smith M.A., Morton C.L., Keshelava N., Houghton P.J.,
RA   Reynolds C.P.;
RT   "National Cancer Institute pediatric preclinical testing program:
RT   model description for in vitro cytotoxicity testing.";
RL   Pediatr. Blood Cancer 56:239-249(2011).
//
RX   PubMed=35354797; DOI=10.1038/s41467-022-29224-5;
RA   Leo I.R., Aswad L., Stahl M., Kunold E., Post F., Erkers T.,
RA   Struyf N., Mermelekas G., Joshi R.N., Gracia-Villacampa E.,
RA   Ostling P., Kallioniemi O.-P., Pokrovskaja Tamm K., Siavelis I.,
RA   Lehtio J., Vesterlund M., Jafari R.;
RT   "Integrative multi-omics and drug response profiling of childhood
RT   acute lymphoblastic leukemia cell lines.";
RL   Nat. Commun. 13:1691.1-1691.19(2022).
//